Evidence map›Paper›PMID 29273637›Full record

SynthesisJournal of the American Heart Association2017

New-Onset Atrial Fibrillation After Coronary Artery Bypass Graft and Long-Term Risk of Stroke: A Meta-Analysis.

Matthew R Megens, Leonid Churilov, Vincent Thijs

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03702582 (Trial of New Oral Anticoagulants vs. Warfarin for Post Cardiac Surgery Atrial Fibrillation), which is not on this map. Cited by 20 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 6 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03702582 phase3completednot on this mapstarted 2019, after this paper: background citation

Trial of New Oral Anticoagulants vs. Warfarin for Post Cardiac Surgery Atrial Fibrillation

TypeinterventionalSponsorMassachusetts General HospitalRan2019 to 2023Enrolled100ConditionsAtrial Fibrillation, Stroke, BleedingArmsRivaroxaban, Warfarin
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  12. Predictors and clinical outcomes of post-coronary artery bypass grafting cerebrovascular strokes.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2022
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  18. Non-vitamin K oral anticoagulant use after cardiac surgery is rapidly increasing.The Journal of thoracic and cardiovascular surgery · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Matthew R MegensFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
Leonid ChurilovFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
Vincent ThijsFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia vincent.thijs@florey.edu.au.
University of Melbourne · AUAustin Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNew-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term risk of stroke and mortality. We investigated whether the long-term risk of stroke is increased. METHODS AND

resultsWe performed a systematic review and meta-analysis of studies that included patients who had coronary artery bypass graft and who afterwards developed NOAF during their index admission; these patients did not have previous atrial fibrillation. The primary outcome was risk of stroke at 6 months or more in patients who developed NOAF compared with those who did not. Odds ratios, relative risk, and hazard ratios were considered equivalent; outcomes were pooled on the log-ratio scale using a random-effects model and reported as exponentiated effect-sizes. We included 16 studies, comprising 108 711 participants with a median follow-up period of 2.05 years. Average participant age was 66.8 years, with studies including an average of 74.8% males. There was an increased long-term risk of stroke in the presence of NOAF (unadjusted studies effect-sizes=1.36, 95% confidence interval, 1.12-1.65,

conclusionsPresence of NOAF in patients post-coronary artery bypass graft is associated with increased long-term risk of stroke compared with patients without NOAF. Further studies may show whether the increased risk is mediated by atrial fibrillation and whether anticoagulation reduces risk.

Indexed as

Atrial FibrillationCoronary Artery BypassCoronary Artery DiseaseGlobal HealthHumansIncidenceOdds RatioRisk FactorsStrokeTime Factorsatrial fibrillationcoronary artery bypass surgerycoronary artery graft surgerymeta‐analysisstrokesystematic review

Identifiers

PMID29273637
PMCPMC5779055
OpenAlexW2779623069

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.