Evidence map›Paper›PMID 29273634›Full record

ArticleThe Journal of biological chemistry2018

Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice.

Julia M Fraile, Diana Campos-Iglesias, Francisco Rodríguez, Aurora Astudillo, Roser Vilarrasa-Blasi, Nuria Verdaguer-Dot, Miguel A Prado, Joao A Paulo, Steven P Gygi, José I Martín-Subero and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 68 citations in OpenAlex.

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  15. Article
  16. Deubiquitylating Enzymes in Cancer and Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer.Journal of experimental & clinical cancer research : CR · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Julia M FraileFrom the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain.
Diana Campos-IglesiasFrom the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain.
Francisco RodríguezFrom the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain.
Aurora Astudillothe Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain.
Roser Vilarrasa-Blasithe Departamento de Anatomía Patológica, Farmacología y Microbiología, Universitat de Barcelona, IDIBAPS, 08036-Barcelona, Spain.
Nuria Verdaguer-Dotthe Departamento de Anatomía Patológica, Farmacología y Microbiología, Universitat de Barcelona, IDIBAPS, 08036-Barcelona, Spain.
Miguel A Pradothe Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, and.
Joao A Paulothe Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, and.
Steven P Gygithe Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, and.
José I Martín-Suberothe Departamento de Anatomía Patológica, Farmacología y Microbiología, Universitat de Barcelona, IDIBAPS, 08036-Barcelona, Spain.
José M P FreijeFrom the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain, jmpf@uniovi.es.ORCID 0000-0002-4688-8266
Carlos López-OtínFrom the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain, clo@uniovi.es.
Universidad de Oviedo · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHarvard University · USHospital Universitario Central de Asturias · ES

Funding

Resolving the role of nicotine-mediated phosphorylation on pancreatic fibrosisK01DK098285 · NIDDK · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2013 to 2017
$638k
NIDDK NIH HHS K01 DK098285
6 · The paper itself

Abstract

Deubiquitinases are proteases with a wide functional diversity that profoundly impact multiple biological processes. Among them, the ubiquitin-specific protease 36 (USP36) has been implicated in the regulation of nucleolar activity. However, its functional relevance

Indexed as

BlastocystAnimalsApoptosisCell Line, TumorCell ProliferationDEAD-box RNA HelicasesDeubiquitinating EnzymesEmbryo LossHumansMiceMice, KnockoutProtein BiosynthesisProtein StabilityRNA HelicasesRNA, RibosomalUbiquitin ThiolesteraseDEAD-box RNA HelicasesDeubiquitinating EnzymesDHX33 protein, mouseRNA HelicasesRNA, RibosomalUbiquitin ThiolesteraseUsp36 protein, mousedeubiquitylation (deubiquitination)nucleolusproteaseprotein synthesisribosome

Identifiers

PMID29273634
PMCPMC5808777
OpenAlexW2779054843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.