ArticleDevelopmental biology2018
PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets.
Article in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
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- Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development.JCI insight · 2024Article
- Sall genes regulate hindlimb initiation in mouse embryos.Genetics · 2024Article
- Candidate Regulatory Genes for Hindlimb Development in the Embryos of the Chinese Alligator (Animals : an open access journal from MDPI · 2023Article
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- Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging.Cell reports · 2023Article
- Identification of potential key variants in mandibular premolar hypodontia through whole-exome sequencing.Frontiers in genetics · 2023Article
- PITX1 plays essential functions in cancer.Frontiers in oncology · 2023Review
- Joint disease-specificity at the regulatory base-pair level.Nature communications · 2021Article
- Pitx genes in development and disease.Cellular and molecular life sciences : CMLS · 2021Review
- A single cell transcriptional atlas of early synovial joint development.Development (Cambridge, England) · 2020Article
- Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep.Animals : an open access journal from MDPI · 2020Article
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- Pigeon foot feathering reveals conserved limb identity networks.Developmental biology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The PITX1 transcription factor is expressed during hindlimb development, where it plays a critical role in directing hindlimb growth and the specification of hindlimb morphology. While it is known that PITX1 regulates hindlimb formation, in part, through activation of the Tbx4 gene, other transcriptional targets remain to be elucidated. We have used a combination of ChIP-seq and RNA-seq to investigate enhancer regions and target genes that are directly regulated by PITX1 in embryonic mouse hindlimbs. In addition, we have analyzed PITX1 binding sites in hindlimbs of Anolis lizards to identify ancient PITX1 regulatory targets. We find that PITX1-bound regions in both mouse and Anolis hindlimbs are strongly associated with genes implicated in limb and skeletal system development. Gene expression analyses reveal a large number of misexpressed genes in the hindlimbs of Pitx1
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Registered trials
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