ArticleKidney international2018
Global glomerulosclerosis with nephrotic syndrome; the clinical importance of age adjustment.
Article in Kidney international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- IPNA clinical practice recommendations for the diagnosis and management of children with steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2020Guideline
- Renal function-improving action of Pentadecyl®, a multifunctional triglyceride fromExperimental and therapeutic medicine · 2026Article
- Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification.medRxiv : the preprint server for health sciences · 2026Article
- FSTIV score is essential for clinical management and predicts outcome of idiopathic membranous nephropathy.BMC nephrology · 2026Article
- Glomerular Segmentation, Classification, and Pathomic Feature-based Prediction of Clinical Outcomes in Minimal Change Disease and Focal Segmental Glomerulosclerosis.medRxiv : the preprint server for health sciences · 2025Article
- Patterns of Glomerular Injury: Histopathological Classification and Clinical Correlation.Cureus · 2025Review
- Recurrent paraneoplastic nephrotic syndrome; insights from a Lynch syndrome patient with multiple malignancies.Familial cancer · 2024Article
- PatchSorter: a high throughput deep learning digital pathology tool for object labeling.NPJ digital medicine · 2024Article
- Remission induced by renal protective therapy in nephrotic syndrome with thin basement membrane in an older patient: a case report.Journal of medical case reports · 2024Article
- Risk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis: a nationwide retrospective study in China.World journal of pediatrics : WJP · 2024Article
- A new index for the outcome of focal segmental glomerulosclerosis.Scientific reports · 2024Article
- Morphometric analysis of chronicity on kidney biopsy: a useful prognostic exercise.Clinical kidney journal · 2024Review
- The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome-a NEPTUNE cohort study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study.BMJ (Clinical research ed.) · 2023Article
- Mild to moderate decrease in eGFR and cognitive decline in older adults.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Observational
- Quantitative morphometrics reveals glomerular changes in patients with infrequent segmentally sclerosed glomeruli.Journal of clinical pathology · 2022Article
- Holistic fine-grained global glomerulosclerosis characterization: from detection to unbalanced classification.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Development and evaluation of deep learning-based segmentation of histologic structures in the kidney cortex with multiple histologic stains.Kidney international · 2021Article
- Digital pathology and computational image analysis in nephropathology.Nature reviews. Nephrology · 2020Review
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Abstract
Globally sclerotic glomeruli (GSG) occur with both normal aging and kidney disease. However, it is unknown whether any GSG or only GSG exceeding that expected for age is clinically important. To evaluate this, we identified patients with a glomerulopathy that often presents with nephrotic syndrome (focal segmental glomerulosclerosis, membranous nephropathy, or minimal change disease) in the setting of the Nephrotic Syndrome Study Network (NEPTUNE), China-Digital Kidney Pathology (DiKiP), and the Southeast Minnesota cohorts. Age-based thresholds (95th percentile) for GSG based on normotensive living kidney donors were used to classify each patient into one of three groups; no GSG, GSG normal for age, or GSG abnormal for age. The risk of end-stage renal disease or a 40% decline in glomerular filtration rate during follow-up was then compared between groups. Among the 425 patients studied, 170 had no GSG, 107 had GSG normal for age, and 148 had GSG abnormal for age. Compared to those with no GSG, the risk of kidney disease progression with GSG normal for age was similar but was significantly higher with GSG abnormal for age. This increased risk with GSG abnormal for age remained significant after adjustment for interstitial fibrosis, arteriosclerosis, age, hypertension, diabetes, body mass index, glomerulopathy type, glomerular filtration rate, and proteinuria. Thus, in patients with glomerulopathy that often presents with nephrotic syndrome, global glomerulosclerosis is clinically important only if it exceeds that expected for age.
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