Evidence map›Paper›PMID 29273316›Full record

ArticleSexual medicine2018

Quantitative Assessment and Interpretation of Vaginal Conditions.

Vladimir Egorov, Miles Murphy, Vincent Lucente, Heather van Raalte, Sonya Ephrain, Nina Bhatia, Noune Sarvazyan

Open access · goldAbstract read
In one paragraph

Article in Sexual medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Speculum-free portable preterm imaging system.Journal of biomedical optics · 2024
    Article
  3. Article
  4. Review
  5. An Innovative Design for the Vaginal Speculum.Medical devices (Auckland, N.Z.) · 2023
    Article
  6. Article
  7. Article
  8. Mucosa-interfacing electronics.Nature reviews. Materials · 2022
    Review
  9. Article
  10. Predictive Value of Biomechanical Mapping for Pelvic Organ Prolapse Surgery.Female pelvic medicine & reconstructive surgery · 2021
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vladimir EgorovArtann Laboratories, Trenton, NJ, USA. Electronic address: vegorov@artannlabs.com.
Miles MurphyThe Institute for Female Pelvic Medicine & Reconstructive Surgery, Allentown, PA, USA.
Vincent LucenteThe Institute for Female Pelvic Medicine & Reconstructive Surgery, Allentown, PA, USA.
Heather van RaaltePrinceton Urogynecology, Princeton, NJ, USA.
Sonya EphrainThe Institute for Female Pelvic Medicine & Reconstructive Surgery, Allentown, PA, USA.
Nina BhatiaPrinceton Urogynecology, Princeton, NJ, USA.
Noune SarvazyanArtann Laboratories, Trenton, NJ, USA.
Institute for Female Pelvic Medicine and Reconstructive Surgery · USArtann Laboratories, Inc. · US

Funding

Vaginal Tactile Imager for Pelvic Floor Biomechanical AssessmentR44AG034714 · NIA · ARTANN LABORATORIES, INC. · PI EGOROV, VLADIMIR · 2011 to 2014
$2.6M
Vaginal Tactile Imager for Pelvic Floor Biomechanical AssessmentSB1AG034714 · NIA · ARTANN LABORATORIES, INC. · PI SARVAZYAN, NOUNE · 2016 to 2017
$1.2M
Vaginal Tactile Imager for Pelvic Floor Biomechanical AssessmentR43AG034714 · NIA · ARTANN LABORATORIES, INC. · PI EGOROV, VLADIMIR · 2009 to 2009
$208k
NIA NIH HHS R43 AG034714NIA NIH HHS R44 AG034714NIA NIH HHS SB1 AG034714
6 · The paper itself

Abstract

introductionFew means exist to provide quantitative and reproducible assessment of vaginal conditions from biomechanical and functional standpoints.

aimTo develop a new approach for quantitative biomechanical characterization of the vagina.

methodsVaginal tactile imaging (VTI) allows biomechanical assessment of soft tissue and function along the entire length of the anterior, posterior, and lateral vaginal walls. This can be done at rest, with applied vaginal deformation, and with pelvic muscle contraction.

resultsData were analyzed for 42 subjects with normal pelvic floor support from an observational case-controlled clinical study. The average age was 52 years (range = 26-90 years). We introduced 8 VTI parameters to characterize vaginal conditions: (i) maximum resistance force to insertion (newtons), (ii) insertion work (millijoules), (iii) maximum stress-to-strain ratio (elasticity; kilopascals per millimeter), (iv) maximum pressure at rest (kilopascals), (v) anterior-posterior force at rest (newtons), (vi) left-right force at rest (newtons), (vii) maximum pressure at muscle contraction (kilopascals), and (viii) muscle contraction force (newtons). We observed low to moderate correlation of these parameters with subject age and no correlation with subject weight. 6 of 8 parameters demonstrated a P value less than .05 for 2 subject subsamples divided by age (≤52 vs >52 years), which means 6 VTI parameters change with age.

conclusionsVTI allows biomechanical and functional characterization of the vaginal conditions that can be used for (i) understanding "normal" vaginal conditions, (ii) quantification of the deviation from normality, (iii) personalized treatment (radiofrequency, laser, or plastic surgery), and (iv) assessment of the applied treatment outcome. Egorov V, Murphy M, Lucente V, et al. Quantitative Assessment and Interpretation of Vaginal Conditions. Sex Med 2018;6:39-48.

Indexed as

Tactile ImagingVaginal ConditionsVaginal ElasticityVaginal ForceVaginal PressureVaginal Work

Identifiers

PMID29273316
PMCPMC5815972
OpenAlexW2775954384

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.