Evidence map›Paper›PMID 29273260›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2018

Predicting hypoxia status using a combination of contrast-enhanced computed tomography and [

Mireia Crispin-Ortuzar, Aditya Apte, Milan Grkovski, Jung Hun Oh, Nancy Y Lee, Heiko Schöder, John L Humm, Joseph O Deasy

Abstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 64 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Use of Radiomics in Characterizing Tumor Hypoxia.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Is there a role for [Clinical and translational imaging · 2024
    Article
  9. Review
  10. Review
  11. The application ofQuantitative imaging in medicine and surgery · 2023
    Review
  12. Application of radiomics in lung immuno-oncology.Precision radiation oncology · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Mireia Crispin-OrtuzarDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA; Cancer Research UK Cambridge Institute, University of Cambridge, UK. Electronic address: mireia.crispinortuzar@cruk.cam.ac.uk.
Aditya ApteDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
Milan GrkovskiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
Jung Hun OhDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
Nancy Y LeeDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA.
Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.
John L HummDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
Joseph O DeasyDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Hypoxia Image-Guided Radiation TherapyR01CA157770 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEE, NANCY Y · 2012 to 2016
$2.1M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA157770
6 · The paper itself

Abstract

background and purposeHypoxia is a known prognostic factor in head and neck cancer. Hypoxia imaging PET radiotracers such as

methods121 lesions from 75 head and neck cancer patients were used in the analysis. Patients received pre-treatment

resultsIn the training subset, the highest AUC (0.873±0.008) was obtained from a signature combining CT and

conclusionA radiomics signature built from

Indexed as

Fluorodeoxyglucose F18RadiopharmaceuticalsHead and Neck NeoplasmsHumansMisonidazolePositron Emission Tomography Computed TomographyTumor HypoxiaFluorodeoxyglucose F18fluoromisonidazoleMisonidazoleRadiopharmaceuticalsFDGFMISOHead and neck cancerHypoxiaPETRadiomics

Identifiers

PMID29273260
PMCPMC5924729
OpenAlexW2780987808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.