Evidence map›Paper›PMID 29273092›Full record

ArticleArthritis research & therapy2017

Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study.

Isabel Ferreira, Sara Croca, Maria Gabriella Raimondo, Manjit Matharu, Sarah Miller, Ian Giles, David Isenberg, Yiannis Ioannou, John G Hanly, Murray B Urowitz and 33 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 72% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 9 countries.

Isabel FerreiraCentre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London, WC1E 6JF, UK.
Sara CrocaCentre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London, WC1E 6JF, UK.
Maria Gabriella RaimondoCentre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London, WC1E 6JF, UK.
Manjit MatharuHeadache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Sarah MillerHeadache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Ian GilesCentre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London, WC1E 6JF, UK.
David IsenbergCentre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London, WC1E 6JF, UK.
Yiannis IoannouCentre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London, WC1E 6JF, UK.
John G HanlyDivision of Rheumatology, Dalhousie University and Queen Elizabeth II Health Sciences Center, Halifax, NS, Canada.
Murray B UrowitzLupus Program, Centre for Prognosis Studies in The Rheumatic Disease and Krembil Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.
Nicole AndersonLupus Program, Centre for Prognosis Studies in The Rheumatic Disease and Krembil Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.
Cynthia AranowFeinstein Institute for Medical Research, Manhasset, NY, USA.
Anca AskanaseRheumatology, Columbia University, New York, NY, USA.
Sang-Cheol BaeDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Sasha BernatskyDivisions of Clinical Epidemiology and Rheumatology, McGill University Health Centre, Montreal, QC, Canada.
Ian N BruceArthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Jill BuyonNew York School of Medicine, New York, NY, USA.
Ann E ClarkeDivision of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Mary Anne DooleyThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.
Paul FortinCentre Hospitalier de l'Université Laval (CHUL), Québec, QC, Canada.
Ellen GinzlerDownstate Medical Center Rheumatology, Brooklyn, New York, NY, USA.
Dafna GladmanLupus Program, Centre for Prognosis Studies in The Rheumatic Disease and Krembil Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.
Caroline GordonRheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Murat InancDepartment of Internal Medicine, Istanbul University, Istanbul, Turkey.
Søren JacobsenCopenhagen Lupus and Vasculitis Clinic, Centre For Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.
Kenneth KalunianUniversity of California, San Diego, La Jolla, CA, USA.
Diane KamenDivision of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Munther KhamashtaFRCP Division of Women's Health, King's College, London, UK.
Sam LimDepartment of Medicine, Emory University, Atlanta, GA, USA.
Susan ManziAllegheny Health Network, Pittsburgh, PA, USA.
Joan MerrillClinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Ola NivedDepartment of Rheumatology, Lund University, Lund, Sweden.
Christine PeschkenDepartment of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Michelle PetriJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Rosalind Ramsey-GoldmanNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Guillermo Ruiz-IrastorzaAutoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute. Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain.
Jorge Sanchez-GuerreroMount Sinai Hospital and University Health Network, University of Toronto, Toronto, ON, Canada.
Kristjan SteinsonDepartment of Rheumatology, Landspitali University Hospital, Reykjavik, Iceland.
Gunnar K SturfeltDepartment of Rheumatology, Lund University, Lund, Sweden.
Ronald van VollenhovenRheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Sweden.
Daniel J WallaceCedars-Sinai Medical Center/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Asad ZomaDepartment of Rheumatology Hairmyres Hospital, East Kilbride, Scotland, UK.
Anisur RahmanCentre for Rheumatology Research, University College London, Fourth Floor Rayne Institute, 5 University Street, London, WC1E 6JF, UK. anisur.rahman@ucl.ac.uk.ORCID 0000-0003-2346-4484
University College London · GBUniversity of Toronto · CAGreat Ormond Street Hospital · GBLund University · SENational Hospital for Neurology and Neurosurgery · GBAllegheny Health Network · USCedars-Sinai Medical Center · USCentre hospitalier de l'Université Laval · CAColumbia University · USDalhousie University · CAEmory University · USFeinstein Institute for Medical Research · USHairmyres Hospital · GBHanyang University Seoul Hospital · KRIstanbul University · TRJohns Hopkins University · USKarolinska University Hospital · SEKing's College London · GBManchester Academic Health Science Centre · GBMcGill University Health Centre · CA

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Zonisamide in Patients with Neuropathic Pain Associated with Diabetic NeuropathyM01RR000046 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOY, MELANIE S · 1985 to 2008
$38.5M
MULTIDISCIPLINARY CLINICAL AND TRANSLATIONAL SCIENCE (MCTS) PROGRAM (UL1)UL1RR025741 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREENLAND, PHILIP · 2008 to 2011
$24.7M
Study of Lupus Vascular and Bone Longterm EndpointsP60AR048098 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DUNLOP, DOROTHY D. · 2002 to 2011
$11.4M
Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)UL1TR000150 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2012 to 2013
$10.1M
Lupus CohortR01AR043727 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI PETRI, MICHELLE A · 1997 to 2015
$8.2M
Physical Activity Changes & Thersholds: Quality of Life and Outcomes in Knee OAP60AR064464 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHARMA, LEENA · 2013 to 2017
$4.5M
Arthritis Research UK 19423Arthritis Research UK 20164CIHR MOP-86526NCATS NIH HHS UL1 TR000150NCATS NIH HHS UL1 TR001422NCRR NIH HHS M01 RR000046NCRR NIH HHS UL1 RR025741NIAMS NIH HHS P60 AR048098NIAMS NIH HHS P60 AR064464NIAMS NIH HHS R01 AR043727NIH HHS P60AR064464NIH HHS RR00046Versus Arthritis 19423Wellcome Trust
6 · The paper itself

Abstract

backgroundIn patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE.

methodsWe obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event.

resultsTwenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P = 0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety.

conclusionsSerum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.

Indexed as

AdultBiomarkersCase-Control StudiesFemaleHumansLupus Erythematosus, SystemicLupus Vasculitis, Central Nervous SystemMaleMiddle AgedNucleosomesRetrospective StudiesBiomarkersNucleosomesNeuropsychiatricNitrationNucleosomesSystemic lupus erythematosus

Identifiers

PMID29273092
PMCPMC5741886
OpenAlexW2778816489

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.