Evidence map›Paper›PMID 29273063›Full record

ArticleTrials2017

Nitrous oxide (N

Richard M Stewart, Janice W Y Wong, Kevin C Runions, Pradeep Rao, Julia K Moore, Simon R Davies, Britta S von Ungern-Sternberg, David Sommerfield, Florian Daniel Zepf

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Richard M StewartCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Paediatrics and Child Health & Division of Psychiatry and Clinical Neurosciences, The University of Western Australia, 35 Stirling Highway (M561), Crawley, WA 6009, Perth, Australia.
Janice W Y WongCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Paediatrics and Child Health & Division of Psychiatry and Clinical Neurosciences, The University of Western Australia, 35 Stirling Highway (M561), Crawley, WA 6009, Perth, Australia.
Kevin C RunionsCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Paediatrics and Child Health & Division of Psychiatry and Clinical Neurosciences, The University of Western Australia, 35 Stirling Highway (M561), Crawley, WA 6009, Perth, Australia.
Pradeep RaoCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Paediatrics and Child Health & Division of Psychiatry and Clinical Neurosciences, The University of Western Australia, 35 Stirling Highway (M561), Crawley, WA 6009, Perth, Australia.
Julia K MooreCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Paediatrics and Child Health & Division of Psychiatry and Clinical Neurosciences, The University of Western Australia, 35 Stirling Highway (M561), Crawley, WA 6009, Perth, Australia.
Simon R DaviesCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Paediatrics and Child Health & Division of Psychiatry and Clinical Neurosciences, The University of Western Australia, 35 Stirling Highway (M561), Crawley, WA 6009, Perth, Australia.
Britta S von Ungern-SternbergDepartment of Anaesthesia and Pain Management, Princess Margaret Hospital for Children, Perth, Australia.
David SommerfieldDepartment of Anaesthesia and Pain Management, Princess Margaret Hospital for Children, Perth, Australia.
Florian Daniel ZepfCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Paediatrics and Child Health & Division of Psychiatry and Clinical Neurosciences, The University of Western Australia, 35 Stirling Highway (M561), Crawley, WA 6009, Perth, Australia. florian.zepf@uwa.edu.au.
University of Western Australia · AUPrincess Margaret Hospital for Children · AUThe Kids Research Institute Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe first line of pharmacological treatment for severe depressive disorders in young people is selective serotonin reuptake inhibitors (SSRIs). However, beneficial clinical effects are rarely observed before several weeks into treatment. Nitrous oxide (N METHODS/

designIn this study, we will use a single-blind, randomised, placebo-controlled design. Patients aged between 12 and 17 years with major depressive disorder will be recruited. This study will consist of two phases: phase A and phase B. During phase A, participants will be randomised to receive either inhaled N DISCUSSION: We expect an antidepressant effect from a single dose of inhaled N

trial registrationAustralian and New Zealand Clinical Trials Registry, ACTRN12616001568404 . Registered on 14 November 2016.

Indexed as

AdolescentChildData Interpretation, StatisticalDrug Therapy, CombinationFluoxetineHumansMajor Depressive DisorderNitrous OxideRandomized Controlled Trials as TopicSelective Serotonin Reuptake InhibitorsSingle-Blind MethodFluoxetineNitrous OxideSelective Serotonin Reuptake InhibitorsAdolescentsChildrenDepressionMood disordersNeuroscienceNitrous oxideNMDAPsychopharmacology

Identifiers

PMID29273063
PMCPMC5741960
OpenAlexW2778082407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.