Evidence map›Paper›PMID 29272704›Full record

ArticleMolecular cell2017

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection.

Thomas Vierbuchen, Emi Ling, Christopher J Cowley, Cameron H Couch, Xiaofeng Wang, David A Harmin, Charles W M Roberts, Michael E Greenberg

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 311 papers.

0numbers the graph read from it
0cells of the map it votes in
311citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

311 citing papers in PubMed, 487 citations in OpenAlex.

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251 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Thomas Vierbuchen *Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address: tvierbuchen@gmail.com.
Emi Ling *Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Christopher J CowleyDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Cameron H CouchDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Xiaofeng WangDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
David A HarminDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Charles W M RobertsComprehensive Cancer Center and Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michael E GreenbergDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Harvard University · USDana-Farber Cancer Institute · USSt. Jude Children's Research Hospital · US

Funding

ELECTRICAL STIMULATION OF IMMEDIATE EARLY GENESR37NS028829 · NINDS · HARVARD MEDICAL SCHOOL · PI GREENBERG, MICHAEL ELDON · 1999 to 2019
$7.4M
Neuronal Activity-Dependent Regulation of MeCP2R01NS048276 · NINDS · HARVARD MEDICAL SCHOOL · PI GREENBERG, MICHAEL ELDON · 2004 to 2019
$6.9M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SAHIN, MUSTAFA · 2016 to 2020
$5.2M
Role of SNF5 in regulating SWI/SNF complex assembly & targeting in rhabdoid tumorK99CA197640 · NCI · DANA-FARBER CANCER INST · PI WANG, XIAOFENG · 2016 to 2017
$303k
Howard Hughes Medical InstituteNCI NIH HHS K99 CA197640NICHD NIH HHS U54 HD090255NINDS NIH HHS R01 NS048276NINDS NIH HHS R37 NS028829
6 · The paper itself

Abstract

Enhancer elements are genomic regulatory sequences that direct the selective expression of genes so that genetically identical cells can differentiate and acquire the highly specialized forms and functions required to build a functioning animal. To differentiate, cells must select from among the ∼10

Indexed as

Enhancer Elements, GeneticAnimalsChromatinChromosomal Proteins, Non-HistoneFemaleGene Expression Regulation, NeoplasticMaleMice, Inbred C57BLMice, KnockoutNucleosomesPromoter Regions, GeneticProto-Oncogene Proteins c-fosTranscription FactorsChromatinChromosomal Proteins, Non-HistoneFosb protein, mouseJunB protein, mouseNucleosomesProto-Oncogene Proteins c-fosSWI-SNF-B chromatin-remodeling complexTranscription Factorschromatin remodeling complexesenhancersgeneticsgenomicsgrowth factor signalinglineage specificationmSWI/SNF (BAF) complexesRas/MAPK signalingtranscriptional regulationtranscription factors

Identifiers

PMID29272704
PMCPMC5744881
OpenAlexW2779662045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.