ArticlePloS one2017
Independent relationship between serum ferritin levels and dyslipidemia in Chinese adults: A population study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Evaluation of progressive muscle relaxation and autonomous sensory meridian response in alleviating dental anxiety in children aged 7-11 years: a randomized controlled trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Trial
- Serum ferritin associated with atherogenic lipid profiles in a high-altitude living general population.PeerJ · 2025Article
- Associations Between Genetically Predicted Iron Status and Cardiovascular Disease Risk: A Mendelian Randomization Study.Journal of the American Heart Association · 2024Article
- Association Between Multiple Heavy Metal Exposures and Cholesterol Levels in Residents Living Near a Smelter Plant in Korea.Journal of Korean medical science · 2024Article
- Characterising heart rhythm abnormalities associated with Xp22.31 deletion.Journal of medical genetics · 2023Article
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- Association of gestational hypertriglyceridemia, diabetes with serum ferritin levels in early pregnancy: a retrospective cohort study.Frontiers in endocrinology · 2023Article
- Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents.International journal of environmental research and public health · 2022Article
- The Association Between METS-IR and Serum Ferritin Level in United States Female: A Cross-Sectional Study Based on NHANES.Frontiers in medicine · 2022Article
- Correlations Between Iron Status and Body Composition in Patients With Type 2 Diabetes Mellitus.Frontiers in nutrition · 2022Article
- Ferritin, transferrin, and transferrin receptor in relation to metabolic obesity phenotypes: Findings from the China Health and Nutrition Survey.Frontiers in public health · 2022Article
- Association of dyslipidemia, diabetes and metabolic syndrome with serum ferritin levels: a middle eastern population-based cross-sectional study.Scientific reports · 2021Article
- Circadian variations in the occurrence of first-ever intracerebral hemorrhage from different sources of income: a hospital-based cross-sectional study.BMC neurology · 2021Article
- Combined Associations of Serum Ferritin and Body Size Phenotypes With Cardiovascular Risk Profiles: A Chinese Population-Based Study.Frontiers in public health · 2021Article
- The Causal Effects of Blood Iron and Copper on Lipid Metabolism Diseases: Evidence from Phenome-Wide Mendelian Randomization Study.Nutrients · 2020Article
- Correlations between Iron Metabolism Parameters, Inflammatory Markers and Lipid Profile Indicators in Patients with Type 1 and Type 2 Diabetes Mellitus.Journal of personalized medicine · 2020Article
- Associations of iron status with apolipoproteins and lipid ratios: a cross-sectional study from the China Health and Nutrition Survey.Lipids in health and disease · 2020Article
- Association of serum ferritin with metabolic syndrome in eight cities in China.Food science & nutrition · 2020Article
- Elevated blood pressure level based on 2017 ACC/AHA guideline in relation to stroke risk in rural areas of Liaoning province.BMC cardiovascular disorders · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSeveral studies have indicated that elevated levels of circulating ferritin are associated with disturbances in energy metabolism. But none of this gave a clearly pathologic mechanism. We aimed to explore the independent relationship between serum ferritin levels and dyslipidemia.
methodsWe performed multivariable logistic regression analyses to estimate the odds ratios (ORs) for dyslipidemia, lipid parameters, the homeostasis model assessment of insulin resistance (HOMA-IR) and the risk of diabetes, according to sex-specific quartiles of serum ferritin by using the data of China Health and Nutrition Survey (2009 CHNS). We used three models to estimate the strength of the correlation. The basic model (Model 1) is without adjustment and the Model 2 and Model 3 are adjusted for demographic, anthropometric, and lifestyle confounding factors.
resultsIn both genders, the ORs for high TG level, TC level and LDL-C level increased progressively and for HDL-C decreased across the ferritin quartiles (P<0.001 for trend). After adjustment for confounding factors in different logistic regression models, the results remained unchanged. The ORs for the risk of diabetes and high HOMA-IR level in the highest quartile group of serum ferritin levels were significantly increased in Model 1, but after adjustment for lipid parameters, the ORs for the risk of diabetes was decreased from 1.91 (95% CI: 1.37-2.67; P<0.001 for trend) to 1.48 (95% CI: 1.03-2.12; P = 0.036 for trend) in men, and from 5.40 (95% CI: 3.38-8.63; P<0.001 for trend) to 1.43 (95% CI: 0.83-2.43; P = 0.498 for trend) in women, and the ORs for IR was decreased from 1.86 (95% CI: 1.57-2.20; P<0.001 for trend) to 1.25 (95% CI: 1.05-1.50; P = 0.114 for trend) in men, and from 1.93 (95% CI: 1.63-2.28; P<0.001 for trend) to 1.24 (95% CI: 1.01-1.51; P = 0.012 for trend) in women.
conclusionOur results provide evidence that serum ferritin levels are significantly associated with lipid parameters, independent of glucose metabolism disorders and components of metabolic syndrome (MetS). Thus, serum ferritin plays a key role in energy metabolism disorders and may affect glucose metabolism through lipid metabolism.
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