ReviewMaterials (Basel, Switzerland)2017
The Components of Bone and What They Can Teach Us about Regeneration.
Review in Materials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial.Stem cell research & therapy · 2018Trial
- A newly designed flexible hydrated-hardening bone graft (FHBG) promotes bone regeneration and in vivo calvarial repair.Biomedical journal · 2025Article
- Osteoporosis: molecular pathogenesis and therapeutic interventions.Molecular biomedicine · 2025Review
- The Effects and Mechanisms of Low-Intensity Pulsed Ultrasound on Bone Remodeling: From Laboratory to Clinic.Biomolecules · 2025Review
- Improved Biomineralization Using Cellulose Acetate/Magnetic Nanoparticles Composite Membranes.Polymers · 2025Article
- Pleiotropic effects of a recessive Col1a2 mutation occurring in a mouse model of severe osteogenesis imperfecta.PloS one · 2025Article
- Fabrication and Characterization of Electrospun Sr/Zn-Doped Nano-Hydroxyapatite-Collagen-PLGA Nanofibrous Scaffolds for Bone Tissue Engineering.International journal of nanomedicine · 2025Article
- Optimization Design and SLM Manufacturing of Porous Titanium Alloy Femoral Stem.Materials (Basel, Switzerland) · 2024Article
- Review
- Insights and implications of sexual dimorphism in osteoporosis.Bone research · 2024Review
- Generative design approach to combine architected Voronoi foams with porous collagen scaffolds to create a tunable composite biomaterial.Acta biomaterialia · 2023Article
- Evaluation of Gelatin/Hyaluronic Acid-Generated Bridging in a 3D-Printed Titanium Cage for Bone Regeneration.Journal of functional biomaterials · 2023Article
- Research progress of biomimetic materials in oral medicine.Journal of biological engineering · 2023Review
- Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism.Frontiers in veterinary science · 2023Review
- Article
- Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering.International journal of molecular sciences · 2022Review
- Review
- Age Related Osteoporosis: Targeting Cellular Senescence.International journal of molecular sciences · 2022Review
- Therapeutic Treatments for Osteoporosis-Which Combination of Pills Is the Best among the Bad?International journal of molecular sciences · 2022Review
- Manufacturing artificial bone allografts: a perspective.Biomaterials translational · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The problem of bone regeneration has engaged both physicians and scientists since the beginning of medicine. Not only can bone heal itself following most injuries, but when it does, the regenerated tissue is often indistinguishable from healthy bone. Problems arise, however, when bone does not heal properly, or when new tissue is needed, such as when two vertebrae are required to fuse to stabilize adjacent spine segments. Despite centuries of research, such procedures still require improved therapeutic methods to be devised. Autologous bone harvesting and grafting is currently still the accepted benchmark, despite drawbacks for clinicians and patients that include limited amounts, donor site morbidity, and variable quality. The necessity for an alternative to this "gold standard" has given rise to a bone-graft and substitute industry, with its central conundrum: what is the best way to regenerate bone? In this review, we dissect bone anatomy to summarize our current understanding of its constituents. We then look at how various components have been employed to improve bone regeneration. Evolving strategies for bone regeneration are then considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.