Evidence map›Paper›PMID 29271932›Full record

ArticleMaterials (Basel, Switzerland)2017

3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds.

Michael Seidenstuecker, Laura Kerr, Anke Bernstein, Hermann O Mayr, Norbert P Suedkamp, Rainer Gadow, Peter Krieg, Sergio Hernandez Latorre, Ralf Thomann, Frank Syrowatka and 1 more

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael SeidenstueckerDepartment of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. Michael.seidenstuecker@uniklinik-freiburg.de.ORCID 0000-0001-6643-6358
Laura KerrDepartment of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. laurak1@hotmail.co.uk.
Anke BernsteinDepartment of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. anke.bernstein@uniklinik-freiburg.de.
Hermann O MayrDepartment of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. hermann.mayr@uniklinik-freiburg.de.
Norbert P SuedkampDepartment of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. norbert.suedkamp@uniklinik-freiburg.de.
Rainer GadowInstitute for Manufacturing Technologies of Ceramic Components and Composites, University of Stuttgart, Allmandring 7b, D-70569 Stuttgart, Germany. Rainer.Gadow@ifkb.uni-stuttgart.de.ORCID 0000-0002-0207-4033
Peter KriegInstitute for Manufacturing Technologies of Ceramic Components and Composites, University of Stuttgart, Allmandring 7b, D-70569 Stuttgart, Germany. peter.krieg@ifkb.uni-stuttgart.de.
Sergio Hernandez LatorreDepartment of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. sergio.latorre@uniklinik-freiburg.de.
Ralf ThomannFMF-Freiburg Materials Research Center, University of Freiburg, Stefan-Meier-Str. 21, D-79104 Freiburg, Germany. ralf.thomann@fmf.uni-freiburg.de.
Frank SyrowatkaInterdisciplinary Center of Materials Science (CMAT), Martin Luther University Halle, Heinrich Damerow Str. 4, D-06120 Halle, Germany. syrowatka@cmat.uni-halle.de.
Steffen EsslingerInstitute for Manufacturing Technologies of Ceramic Components and Composites, University of Stuttgart, Allmandring 7b, D-70569 Stuttgart, Germany. Steffen.Esslinger@gsame.uni-stuttgart.de.ORCID 0000-0002-2266-7522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of both bioglass (BG) and β tricalcium phosphate (β-TCP) for bone replacement applications has been studied extensively due to the materials' high biocompatibility and ability to resorb when implanted in the body. 3D printing has been explored as a fast and versatile technique for the fabrication of porous bone scaffolds. This project investigates the effects of using different combinations of a composite BG and β-TCP powder for 3D printing of porous bone scaffolds. Porous 3D powder printed bone scaffolds of BG, β-TCP, 50/50 BG/β-TCP and 70/30 BG/β-TCP compositions were subject to a variety of characterization and biocompatibility tests. The porosity characteristics, surface roughness, mechanical strength, viability for cell proliferation, material cytotoxicity and in vitro bioactivity were assessed. The results show that the scaffolds can support osteoblast-like MG-63 cells growth both on the surface of and within the scaffold material and do not show alarming cytotoxicity; the porosity and surface characteristics of the scaffolds are appropriate. Of the two tested composite materials, the 70/30 BG/β-TCP scaffold proved to be superior in terms of biocompatibility and mechanical strength. The mechanical strength of the scaffolds makes them unsuitable for load bearing applications. However, they can be useful for other applications such as bone fillers.

Indexed as

3D printingbiocompatibility in vitrobioglassbone scaffoldsβ-TCP

Identifiers

PMID29271932
PMCPMC5793511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.