Evidence map›Paper›PMID 29271576›Full record

SynthesisTherapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy2018

Effects of Omega-3 Fatty Acids on Markers of Inflammation in Patients With Chronic Kidney Disease: A Controversial Issue.

Chun Hu, Ming Yang, Xuejing Zhu, Peng Gao, Shikun Yang, Yachun Han, Xianghui Chen, Li Xiao, Shuguang Yuan, Fuyou Liu and 2 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Effects of Vitamin DNutrients · 2022
    Trial
  4. Decoding blood fatty acids in Crimean-Congo hemorrhagic fever.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Chun HuDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.ORCID http://orcid.org/0000-0003-4597-1786
Ming YangDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Xuejing ZhuDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Peng GaoDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Shikun YangDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Yachun HanDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Xianghui ChenDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Li XiaoDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Shuguang YuanDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Fuyou LiuDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Yashpal S KanwarDepartment of Pathology, Northwestern University, Chicago, IL, USA.
Lin SunDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNNorthwestern University · US

Funding

Pathogenesis of Diabetic NephropathyR01DK060635 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QUAGGIN, SUSAN E. · 2002 to 2023
$6.6M
Intramural NIH HHS Z99 EY999999NIDDK NIH HHS R01 DK060635
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a global problem which contributes to a significant morbidity and mortality in China. Concomitant inflammatory state further boosts the mortality due to cardiovascular events in patients with CKD undergoing dialysis. There is a general notion that Omega-3 fatty acids including docosahexaenoic acids (DHA) and eicosapentaenoic (EPA) have certain health benefits perhaps via the regulation of inflammation. However, the anti-inflammatory effect of omega-3 fatty acids in patients with CKD is controversial. We analyzed the data of oral supplementation of omega-3 fatty acids in CKD patients by searching literature on database from inception to August 2016. The analysis included randomized controlled trials (RCTs) derived from multiple databases, and the effect of omega-3 fatty acids supplementation versus the control cohorts were compared. All of the data analysis was calculated by RevMan 5.2. A total of 12 RCTs involving 487 patients were included in the meta-analysis. Among them 254 patients received omega-3 fatty acids and 233 patients served as controls who received placebo. The meta-analysis revealed no statistical significance in serum levels of C-reactive protein (CRP) (SMD, -0.20; 95% CI, -0.44 to 0.05; P = 0.11), IL-6 (SMD, 0.00; 95% CI, -0.33 to 0.33; P = 0.99) and TNF-α (SMD, 0.14; 95% CI, -0.17 to 0.44; P = 0.38) between the omega-3 fatty acids supplementation group and control. This suggested that there is insufficient evidence to conclude the benefit of omega-3 fatty acids oral supplementation in reducing serum levels of CRP, IL-6 and TNF-α in patients with CKD.

Indexed as

BiomarkersChinaC-Reactive ProteinFatty Acids, Omega-3HumansInflammationRandomized Controlled Trials as TopicRenal DialysisRenal Insufficiency, ChronicBiomarkersC-Reactive ProteinFatty Acids, Omega-3Chronic kidney diseaseC-reactive proteinDialysisInterleukin-6Omega-3 fatty acidsTumor necrosis factor-α

Identifiers

PMID29271576
PMCPMC5880693
OpenAlexW2779212694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.