Evidence map›Paper›PMID 29271129›Full record

ArticleClinical obesity2018

Shorter preschool, leukocyte telomere length is associated with obesity at age 9 in Latino children.

T W Kjaer, D Faurholt-Jepsen, K M Mehta, V B Christensen, E Epel, J Lin, E Blackburn, J M Wojcicki

Open access · greenAbstract read
In one paragraph

Article in Clinical obesity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

T W KjaerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
D Faurholt-JepsenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
K M MehtaDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
V B ChristensenDepartment of Pediatrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
E EpelDepartment of Psychiatry, University of California San Francisco, San Francisco, CA, USA.
J LinDepartment of Biophysics and Biochemistry, University of California San Francisco, San Francisco, CA, USA.
E BlackburnDepartment of Biophysics and Biochemistry, University of California San Francisco, San Francisco, CA, USA.
J M WojcickiDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of San Francisco · USCopenhagen University Hospital · DKIT University of Copenhagen · DKUniversity of Copenhagen · DK

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Maternal Depression and Child Weight Gain in a Latino CohortK01DK080825 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOJCICKI, JANET M · 2009 to 2014
$721k
NCRR NIH HHS UL1 RR024131NIDDK NIH HHS K01 DK080825NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

The aim of this study was to determine the potential role of leukocyte telomere length as a biomarker for development of childhood obesity in a low-income Latino population. A birth cohort of Latino children (N = 201) in San Francisco (recruited May 2006-May 2007) was followed until age 9 and assessed annually for obesity and dietary intake. Leukocyte telomere length was measured at 4 and 5 years (n = 102) and assessed as a predictor for obesity at age 9, adjusting for known risk factors. Furthermore, leukocyte telomere length at age 4 and 5 was evaluated as a possible mediator of the relationship between excessive sugar-sweetened beverage consumption and obesity at age 9. Shorter leukocyte telomere length in preschoolers was associated with obesity at age 9 (adjusted odds ratio 0.35, 95% confidence interval 0.13-0.94) after adjustment for known risk factors. Telomere length mediated 11% of the relationship between excessive sugar-sweetened beverage consumption and obesity. Shorter leukocyte telomere length may be an indicator of future obesity risk in high-risk populations as it is particularly sensitive to damage from oxidative stress exposure, including those from sugar-sweetened beverages.

Indexed as

BeveragesChildCohort StudiesEnergy IntakeFemaleFollow-Up StudiesHispanic or LatinoHumansLeukocytesMalePediatric ObesityRisk FactorsSan FranciscoSugarsTelomereSugarschildhood obesityLatinosleukocyte telomere lengthsugar-sweetened beverage

Identifiers

PMID29271129
PMCPMC5842114
OpenAlexW2779587789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.