Evidence map›Paper›PMID 29270892›Full record

ArticleNeuroinformatics2018

Multi-Table Differential Correlation Analysis of Neuroanatomical and Cognitive Interactions in Turner Syndrome.

Christof Seiler, Tamar Green, David Hong, Lindsay Chromik, Lynne Huffman, Susan Holmes, Allan L Reiss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroinformatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sex chromosome aneuploidy alters the relationship between neuroanatomy and cognition.American journal of medical genetics. Part C, Seminars in medical genetics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christof SeilerDepartment of Statistics, Stanford University, Stanford, CA, USA. christof.seiler@stanford.edu.
Tamar GreenCenter for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA, USA.
David HongCenter for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA, USA.
Lindsay ChromikCenter for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA, USA.
Lynne HuffmanDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Susan HolmesDepartment of Statistics, Stanford University, Stanford, CA, USA.
Allan L ReissCenter for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Gene, Brain and Behavior in Turner SyndromeR01HD049653 · NICHD · STANFORD UNIVERSITY · PI REISS, ALLAN L · 2006 to 2016
$6.0M
Brain and Behavior during Puberty in Klinefelter Syndrome.R01HD092847 · NICHD · STANFORD UNIVERSITY · PI REISS, ALLAN L, ROSS, JUDITH L · 2018 to 2023
$3.4M
Brain Development & Sex Chromosomes: Imaging of Turner and Klinefelter SyndromesR21MH099630 · NIMH · STANFORD UNIVERSITY · PI REISS, ALLAN L · 2013 to 2014
$432k
National Institute of Child Health and Human Development (US) HD049653NICHD NIH HHS R01 HD049653NICHD NIH HHS R01 HD092847NIMH NIH HHS MH099630NIMH NIH HHS R21 MH099630Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 146281Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 158500
6 · The paper itself

Abstract

Girls and women with Turner syndrome (TS) have a completely or partially missing X chromosome. Extensive studies on the impact of TS on neuroanatomy and cognition have been conducted. The integration of neuroanatomical and cognitive information into one consistent analysis through multi-table methods is difficult and most standard tests are underpowered. We propose a new two-sample testing procedure that compares associations between two tables in two groups. The procedure combines multi-table methods with permutation tests. In particular, we construct cluster size test statistics that incorporate spatial dependencies. We apply our new procedure to a newly collected dataset comprising of structural brain scans and cognitive test scores from girls with TS and healthy control participants (age and sex matched). We measure neuroanatomy with Tensor-Based Morphometry (TBM) and cognitive function with Wechsler IQ and NEuroPSYchological tests (NEPSY-II). We compare our multi-table testing procedure to a single-table analysis. Our new procedure reports differential correlations between two voxel clusters and a wide range of cognitive tests whereas the single-table analysis reports no differences. Our findings are consistent with the hypothesis that girls with TS have a different brain-cognition association structure than healthy controls.

Indexed as

Neuropsychological TestsAdolescentBrainChildChild, PreschoolCluster AnalysisCognitionDatabases, FactualFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingTurner SyndromeCognitive abilitiesMulti-table analysisPermutation testsSparse canonical correlation analysisTensor-based morphometryTurner syndrome

Identifiers

PMID29270892
PMCPMC6223630

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.