Evidence map›Paper›PMID 29270848›Full record

ArticleMolecular imaging and biology2018

Role of CT Density in PET/CT-Based Assessment of Lymphoma.

Paul Flechsig, Christina Walker, Clemens Kratochwil, Laila König, Andrei Iagura, Jan Moltz, Tim Holland-Letz, Hans-Ulrich Kauczor, Uwe Haberkorn, Frederik L Giesel

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Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paul FlechsigDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany. paul.flechsig@med.uni-heidelberg.de.
Christina WalkerDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Clemens KratochwilDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Laila KönigDepartment of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.
Andrei IaguraDivision of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, CA, USA.
Jan MoltzFraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany.
Tim Holland-LetzDepartment of Biostatistics, German Cancer Research Center, Heidelberg, Germany.
Hans-Ulrich KauczorTranslational Lung Research Center Heidelberg, Member of the German Center for Lung Research DZL, Heidelberg, Germany.
Uwe HaberkornDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Frederik L GieselDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn patients with Hodgkin (HL) and non-Hodgkin lymphoma (NHL), primary staging, as well as intermediate and late response assessment, is often performed by integrated 2-deoxy-2-[ PROCEDURES: After approval by the institutional review board, 176 lymph nodes (LN) in 90 PET/CT examinations of 90 patients were retrospectively analyzed (HL, 108 TLs out of 55 patients; NHL, 68 TLs out of 35 patients). PET/CT was performed for reasons of primary staging, response evaluation as interim PET, or as final examination after therapy, according to the clinical schedule. Analyses of TLs were performed on the basis of tracer uptake (SUV) 60 min after tracer injection and volumetric CT histogram analysis in non-contrast-enhanced CT.

resultsAll patients were diagnosed with HL or NHL in a pretreatment biopsy. Prior to therapy induction, staging of all patients was performed using contrast-enhanced CT of the neck to the pelvis, or by [

conclusionDensity measurements of TLs in patients with HL and NHL correlate with the dignity of TLs and might therefore serve as a complementary surrogate parameter for the differentiation between malignant and benign TLs. A possible density threshold in clinical routine might be a 20-Hounsfield units (HU) cutoff value to rule out benignancy in TLs that are above the 20-HU threshold.

Indexed as

Positron Emission Tomography Computed TomographyAdultArea Under CurveFemaleHumansLymphomaMaleROC CurveDeauville criteriaFDG-PET-CTLymphomaStaging

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.