Evidence map›Paper›PMID 29270827›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

Chemotherapy-induced nausea and vomiting (CINV) in patients with advanced lung cancer during the first-line treatment: assessment by physicians, nurses, and patients from an Italian multicenter survey.

S Carnio, D Galetta, V Scotti, D L Cortinovis, A Antonuzzo, S Pisconti, A Rossi, O Martelli, F L Cecere, A Lunghi and 11 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06485869 (Impact of Virtual Reality on the Quality of Life of Oncology Patients), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06485869 narecruitingnot on this mapstarted 2023, after this paper: background citation

Impact of Virtual Reality on the Quality of Life of Oncology Patients

TypeinterventionalSponsorCentral Hospital Saint QuentinRan2023 to 2026Enrolled150ConditionsCancerArmsMeasure the improvement in quality of life, Measure the level of satisfaction of patients and nursing staff, Measurement of anxiety and pain, Measurement of depressive state, measuring fatigue levels
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The perception gap of chemotherapy-induced adverse events between doctors and cancer patients: an observational study in China.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Observational
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

S CarnioThoracic Oncology Unit, San Luigi Hospital, University of Turin, Regione Gonzole 10, Orbassano, Turin, Italy. simona.carnio@libero.it.ORCID http://orcid.org/0000-0002-4338-1961
D GalettaClinical Cancer Center "Giovanni Paolo II", Bari, Italy.
V ScottiDepartment of Oncology Radiation Therapy Unit, Careggi University Hospital, Florence, Italy.
D L CortinovisMedical Oncology Unit, San Gerardo Hospital, Monza, Italy.
A AntonuzzoDivision of Medical Oncology Department of Oncology, S. Chiara University Hospital, Pisa, Italy.
S PiscontiDepartment of OncoEmatology Medical Oncology, SG Moscati Hospital, Taranto, Italy.
A RossiDivision of Medical Oncology, SG Moscati Hospital, Avellino, Italy.
O MartelliMedical Oncology Unit, San Giovanni Addolorata Hospital, Rome, Italy.
F L CecereDepartment of Oncology, Medical Oncology Unit, Careggi University Hospital, Florence, Italy.
A LunghiDepartment of Oncology, Medical Oncology Unit, Careggi University Hospital, Florence, Italy.
A Del ConteDepartment of Medical Oncology, Azienda per l'Assistenza Sanitaria No.5, Friuli Occidentale, Presidio Ospedaliero di Pordenone, Pordenone, Italy.
E S MontagnaClinical Cancer Center "Giovanni Paolo II", Bari, Italy.
J TopulliDepartment of Oncology Radiation Therapy Unit, Careggi University Hospital, Florence, Italy.
D PelizzoniMedical Oncology Unit, San Gerardo Hospital, Monza, Italy.
S G RapettiThoracic Oncology Unit, San Luigi Hospital, University of Turin, Regione Gonzole 10, Orbassano, Turin, Italy.
M GianettaThoracic Oncology Unit, San Luigi Hospital, University of Turin, Regione Gonzole 10, Orbassano, Turin, Italy.
M V PacchianaThoracic Oncology Unit, San Luigi Hospital, University of Turin, Regione Gonzole 10, Orbassano, Turin, Italy.
V PegoraroQuintiles IMS, Milan, Italy.
N CataldoQuintiles IMS, Milan, Italy.
E BriaMedical Oncology, Department of Medicine, Verona, Italy.
S NovelloThoracic Oncology Unit, San Luigi Hospital, University of Turin, Regione Gonzole 10, Orbassano, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChemotherapy-induced nausea and vomiting (CINV) still represents a common side-effect of chemotherapy, and often, its perception differs between patients and healthcare professionals. The aim of this study was to evaluate the agreement on the perception of CINV and other items among clinicians, patients, and nurses.

methodsThis observational prospective study was part of an evaluation program promoted by the Women Against Lung Cancer in Europe (WALCE) Onlus. From August 2015 to February 2016, a survey was administered in 11 oncologic institutions to 188 stage IV lung cancer patients and to their oncologists and nurses during first-line chemotherapy. Our survey investigated 11 aspects: anxiety, mood, weakness, appetite, nausea, vomiting, pain, drowsiness, breath, general condition, and trust in treatments. These items were assessed through Numerical Rating Scale at four consecutive evaluations: at T0 (immediately prior to the first cycle), at T1 (immediately prior to the second cycle), at T2 (immediately prior to the third cycle), and at T3 (immediately prior to the fourth cycle). Clinician versus patient (CvP), nurse versus patient (NvP), and clinician versus nurse (CvN) agreements were estimated applying Weighted Cohen's kappa. A multivariate logistic model and generalized equation estimates were applied to evaluate factors possibly influencing CINV development.

resultsThe incidence of patients reporting CINV varied from 40% at T0 to 71% at T3. Both CvP and NvP agreement on the investigated items were mainly moderate, slightly increasing over time, and becoming substantial for some items, in particular for NvP. Pre-chemotherapy anxiety in its mild, moderate, and severe manifestations, as well as mild, moderate, and severe anxiety experienced after chemotherapy start, exposed patients to a higher risk of anticipatory and acute/delayed CINV, respectively.

conclusionsDespite clinical staff awareness of patients' status and perceptions, CINV still represents a clinical problem. This study confirms that particular attention should be paid to anxiety due to its key role in CINV development.

Indexed as

AdultAgedAntiemeticsAntineoplastic AgentsFemaleHumansLung NeoplasmsMaleMiddle AgedNauseaProspective StudiesSurveys and QuestionnairesVomitingAntiemeticsAntineoplastic AgentsAnxietyChemotherapy-induced nausea and vomitingFirst-line treatmentLung cancer

Identifiers

PMID29270827

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.