Evidence map›Paper›PMID 29270783›Full record

ArticleInternational journal of colorectal disease2018

Statin use is not associated with improved 30-day survival in patients undergoing surgery for colorectal cancer.

Tina Fransgaard, Lau Caspar Thygesen, Ismail Gögenur

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Statin therapy and postoperative short-term mortality after rectal cancer surgery.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Tina FransgaardDepartment of Surgery, Zealand University Hospital, Lykkebækvej 1, 4600, Køge, Denmark. tifer@regionsjaelland.dk.ORCID http://orcid.org/0000-0002-5890-5801
Lau Caspar ThygesenNational Institute of Public Health, University of Southern Denmark, Øster Farigmagsgade 5A, 1353, Copenhagen K, Denmark.
Ismail GögenurDepartment of Surgery, Zealand University Hospital, Lykkebækvej 1, 4600, Køge, Denmark.
University of Southern Denmark · DKZealand University Hospital · DKZealand University Hospital Køge · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBesides the lipid-lowering properties, statins are thought to have anti-inflammatory effects and it has been shown that statins directly attenuate the inflammatory stress response after surgical trauma. The aim of the study was to examine the association between preoperative statin use and 30-day mortality as well as postoperative complications after curative-intended surgery for colorectal cancer.

methodsThe study was a Danish nationwide register-based observational study. A total of 29,352 patients undergoing surgery for colorectal cancer between January 1, 2003, and December 31, 2012, were included in the study. At the time of surgery, 5961 were registered as statin users. The outcomes were 30-day mortality and risk of postoperative complications.

resultsThe adjusted hazard ratio of 30-day mortality was 0.91 (95 CI 0.80-1.04, P = 0.16) among statin users compared with the non-statin group. There was no difference between the two groups regarding the risk of infectious complications (sepsis, anastomotic leakage, pneumonia) (odds ratio 0.95, 95% CI 0.86-1.05, P = 0.31). For other postoperative complications (cardiovascular events, stroke, renal failure, respiratory insufficiency, and thromboembolic events), there was no significant difference between the two groups (odds ratio 0.89, 95% CI 0.78-1.01, P = 0.06).

conclusionThe study did not show an improved 30-day survival after surgery for colorectal cancer in patients treated with statins in the year preceding surgery. No overall association with the risk of postoperative complications was shown.

Indexed as

AgedAged, 80 and overColorectal NeoplasmsDose-Response Relationship, DrugFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPostoperative ComplicationsProportional Hazards ModelsRisk FactorsSurvival AnalysisHydroxymethylglutaryl-CoA Reductase InhibitorsColorectal cancerColorectal surgeryPostoperative complicationsStatin

Identifiers

PMID29270783
OpenAlexW2780853758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.