ReviewNeuropsychology review2018
Neurodevelopmental consequences of pediatric cancer and its treatment: applying an early adversity framework to understanding cognitive, behavioral, and emotional outcomes.
Review in Neuropsychology review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Mapping and comparing the quality of life outcomes in childhood and adolescent and young adult cancer survivors: an umbrella review and future directions.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- Pooled it
- "Chemobrain" in childhood cancer survivors-the impact on social, academic, and daily living skills: a qualitative systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Effects of chemotherapy for acute lymphoblastic leukemia on cognitive function in animal models of contemporary protocols: A systematic literature review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Preparing Children for Invasive Medical Cancer Treatment with "My Logbook": Preliminary Results of a Pilot Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025Trial
- Informing Cancer Education and School Reintegration After Childhood Cancer: Metacognitive, Psychosocial, and School-Participation Indicators.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- Smart Pediatric Oncology Tracker of Symptoms (SPOTS), a Web-Based Interface for the Pediatric PRO-CTCAE: Development and Usability Study.JMIR formative research · 2026Article
- Neurobiological and psychological indicators of post-traumatic stress symptoms in children and adolescents treated for a posterior fossa brain tumour.Neuroimage. Reports · 2026Article
- Microvascular and microstructural brain abnormalities in paediatric haematological cancer survivors are related to cognitive deficits: An IVIM-FWI MRI study.British journal of haematology · 2026Article
- Developmental Foundations of Psychosocial Interventions in Pediatric Oncology: A Lifespan Framework for Resilience.Children (Basel, Switzerland) · 2026Review
- Resources are associated with functional outcome and brain morphometry in childhood cancer survivors.Frontiers in oncology · 2026Article
- PICU associated social-emotional adversity in early childhood cancer patients: consequences in neurodevelopment and mental health.Frontiers in oncology · 2026Review
- Altered System-Level Integration Between Working Memory and Gaze Dynamics in Children Treated for Posterior Fossa Tumors.Psychology in Russia : state of the art · 2026Article
- IMplementation of Physical Activity for Children and adolescents on Treatment (IMPACT) for Cancer Diagnoses in Alberta: Protocol for a Single-Arm, Mixed-Methods, Hybrid Effectiveness-Implementation Trial.JMIR research protocols · 2025Article
- Tobacco and other substance co-use among adolescents and young adults with cancer who use tobacco: prevalence and associations with nicotine dependence and depression.Family medicine and community health · 2025Article
- Tumors and their microenvironments: Learning from pediatric brain pathologies.Biochimica et biophysica acta. Reviews on cancer · 2025Review
- Development of Communication and Language Skills in Children with Hematological-Oncological Disorders: Challenges and Perspectives.Children (Basel, Switzerland) · 2025Article
- Late effects of the treatment of childhood cancer.World journal of clinical cases · 2025Article
- Prevalence and characteristics for mental health disorder before and after childhood cancer diagnosis-a statewide population-based study among Medicaid beneficiaries.Frontiers in psychology · 2025Article
- Single cell spatial biology over developmental time can decipher pediatric brain pathologies.Neurobiology of disease · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Today, children are surviving pediatric cancer at unprecedented rates, making it one of modern medicine's true success stories. However, we are increasingly becoming aware of several deleterious effects of cancer and the subsequent "cure" that extend beyond physical sequelae. Indeed, survivors of childhood cancer commonly report cognitive, emotional, and psychological difficulties, including attentional difficulties, anxiety, and posttraumatic stress symptoms (PTSS). Cognitive late- and long-term effects have been largely attributed to neurotoxic effects of cancer treatments (e.g., chemotherapy, cranial irradiation, surgery) on brain development. The role of childhood adversity in pediatric cancer - namely, the presence of a life-threatening disease and endurance of invasive medical procedures - has been largely ignored in the existing neuroscientific literature, despite compelling research by our group and others showing that exposure to more commonly studied adverse childhood experiences (i.e., domestic and community violence, physical, sexual, and emotional abuse) strongly imprints on neural development. While these adverse childhood experiences are different in many ways from the experience of childhood cancer (e.g., context, nature, source), they do share a common element of exposure to threat (i.e., threat to life or physical integrity). Therefore, we argue that the double hit of early threat and cancer treatments likely alters neural development, and ultimately, cognitive, behavioral, and emotional outcomes. In this paper, we (1) review the existing neuroimaging research on child, adolescent, and adult survivors of childhood cancer, (2) summarize gaps in our current understanding, (3) propose a novel neurobiological framework that characterizes childhood cancer as a type of childhood adversity, particularly a form of early threat, focusing on development of the hippocampus and the salience and emotion network (SEN), and (4) outline future directions for research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.