ArticleParasitology research2018
Performance of two immunochromatographic tests for diagnosis of visceral leishmaniasis in patients coinfected with HIV.
Article in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Systematic review on antigens for serodiagnosis of visceral leishmaniasis, with a focus on East Africa.PLoS neglected tropical diseases · 2019Pooled it
- Revisiting visceral leishmaniasis in immunocompromised patients: Ongoing gaps and advances in diagnostics, therapies, and preventive measures.Current research in parasitology & vector-borne diseases · 2026Review
- Impact of age and immune status on the accuracy of rapid diagnostic tests for visceral leishmaniasis in Brazil.PLoS neglected tropical diseases · 2025Article
- Assessment of asymptomaticFrontiers in medicine · 2025Article
- Article
- Diagnostic application of sensitive and specific phage-exposed epitopes for visceral leishmaniasis and human immunodeficiency virus coinfection.Parasitology · 2021Article
- Revisiting the heterogeneous global genomic population structure ofMicrobial genomics · 2021Article
- Molecular Tracking of theFrontiers in cellular and infection microbiology · 2021Review
- A Flow Cytometry-Based Serological Assay to Detect Visceral Leishmaniasis in HIV-Infected Patients.Frontiers in medicine · 2021Article
- Article
- Frequency of Leishmania spp. infection among HIV-infected patients living in an urban area in Brazil: a cross-sectional study.BMC infectious diseases · 2020Article
- An immunoproteomics approach to identifyParasitology · 2020Article
- Article
- Performance of serological tests available in Brazil for the diagnosis of human visceral leishmaniasis.PLoS neglected tropical diseases · 2019Article
- Evaluation of methods for detection of asymptomatic individuals infected with Leishmania infantum in the state of Piauí, Brazil.PLoS neglected tropical diseases · 2019Article
- A rapid diagnostic test for human Visceral Leishmaniasis using novelEmerging microbes & infections · 2019Article
- Evaluation of a new brand of immunochromatographic test for visceral leishmaniasis in Brazil made available from 2018.Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because of visceral leishmaniasis (VL) urbanization and spreading of the human immunodeficiency virus (HIV) infection to rural areas, coinfection has become more common. Here, we compared the accuracy of Kalazar Detect® (KD), an rK39-based immunochromatographic (IC) test, and OrangeLife® (OL), an rK39 + rK28 IC test, for diagnosing VL in patients coinfected with HIV in an endemic area in Brazil. Seventy-six VL patients and 40 patients with other diseases, of which 31 and 21 patients, respectively, were infected with HIV, were examined. The sensitivity of OL and KD tests was 88.89 and 95.45%, respectively, in patients without HIV. The sensitivity dropped to 67.74 and 61.29%, respectively, in coinfected patients. The decrease in sensitivity was not related to a decrease in the production of Leishmania-specific IgG. Because of the low sensitivity of rk39 test in HIV-infected patients, we suggest that patients with negative rK39 results should undergo further investigation with additional serological tests that are not based only on the rK39 antigen and examination of bone marrow aspirates.
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