Evidence map›Paper›PMID 29270758›Full record

ArticleJournal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban2017

Safety and efficacy of etanercept monotherapy for moderate-to-severe plaque psoriasis: A prospective 12-week follow-up study.

Fang Xie, Rui Wang, Zi-Gang Zhao, Xian-Fu Meng, Bi-Wen Lin, Jie Yang, Wen-Juan Wang, Xiang-Yu Ding, Yi Yang, Hua Zhao and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fang XieDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Rui WangDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Zi-Gang ZhaoDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Xian-Fu MengDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Bi-Wen LinDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Jie YangDepartment of Dermatology, Affiliated Hospital of Hebei United University, Medical College of Chinese PLA, Tangshan, 063000, China.
Wen-Juan WangDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Xiang-Yu DingDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Yi YangDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Hua ZhaoDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Cheng-Xin LiDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Heng-Jin LiDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China.
Yong ZhouDepartment of Dermatology, Chinese PLA General Hospital, Medical College of Chinese PLA, Beijing, 100853, China. xzhouyong@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Etanercept has been shown to be effective for the treatment of moderate-to-severe plaque psoriasis. Since most clinical trials examined etanercept in combination with other drugs, the efficacy and safety of etanercept monotherapy for moderate-to-severe plaque psoriasis have not been well established. This prospective study enrolled 61 Chinese patients with moderate-to-severe plaque psoriasis to explore the efficacy and safety of etanercept monotherapy. These patients were treated with etanercept at a subcutaneous dose of 25 mg, twice a week, for 12 weeks. All the 61 patients completed the treatment and showed significant improvement in psoriasis area and severity index (PASI) scores. At 4, 8, and 12 weeks after treatment, the response rates (PASI75) were 0%, 21.31%, and 40.98%, respectively. It was concluded that etanercept monotherapy is efficacious and safe for patients with moderate- to-severe plaque psoriasis.

Indexed as

AdolescentAdultAgedAnti-Inflammatory Agents, Non-SteroidalDrug Administration ScheduleEtanerceptFemaleFollow-Up StudiesHumansImmunosuppressive AgentsInjections, SubcutaneousMaleMiddle AgedPatient SafetyProspective StudiesPsoriasisAnti-Inflammatory Agents, Non-SteroidalEtanerceptImmunosuppressive Agentsefficacyetanerceptplaque psoriasis

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.