Evidence map›Paper›PMID 29270706›Full record

ReviewNeurochemical research2019

Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors.

Ashley J Evans, Sonam Gurung, Jeremy M Henley, Yasuko Nakamura, Kevin A Wilkinson

Open access · hybridAbstract readReview
In one paragraph

Review in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. A Review of Molecular Imaging of Glutamate Receptors.Molecules (Basel, Switzerland) · 2020
    Review
  19. Review
  20. Genetic Architecture and Molecular Neuropathology of Human Cocaine Addiction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ashley J EvansSchool of Biochemistry, Centre for Synaptic Plasticity, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.
Sonam GurungSchool of Biochemistry, Centre for Synaptic Plasticity, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.
Jeremy M HenleySchool of Biochemistry, Centre for Synaptic Plasticity, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK. j.m.henley@bristol.ac.uk.ORCID http://orcid.org/0000-0003-3589-8335
Yasuko NakamuraSchool of Biochemistry, Centre for Synaptic Plasticity, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.
Kevin A WilkinsonSchool of Biochemistry, Centre for Synaptic Plasticity, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK. Kevin.Wilkinson@bristol.ac.uk.
University of Bristol · GB

Funding

Alzheimer's Society 170Biotechnology and Biological Sciences Research Council BB/F00723X/1Biotechnology and Biological Sciences Research Council BB/G012717/1Biotechnology and Biological Sciences Research Council BB/K014358/1Biotechnology and Biological Sciences Research Council BB/K014366British Heart Foundation PG/14/60/31Medical Research Council G0601810Medical Research Council MR/L003791Medical Research Council MR/L003791/1
6 · The paper itself

Abstract

Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease. Here we provide an overview highlighting these new findings about the mechanisms controlling KARs and how KARs, in turn, regulate other proteins and pathways to influence synaptic function.

Indexed as

AnimalsBrainHumansKainic Acid ReceptorsMembrane ProteinsNeuronal PlasticityNeuronsProtein TransportKainic Acid ReceptorsMembrane ProteinsGluK2Kainate receptorsRUSHSynaptic plasticitySynaptic transmissionTrafficking

Identifiers

PMID29270706
PMCPMC6420428
OpenAlexW2779598777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.