ReviewJournal of current ophthalmology2017
Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes.
Review in Journal of current ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Three-year results of accelerated transepithelial cross-linking (30 mW/cmBMJ open ophthalmology · 2022Trial
- Changes in Corneal Densitometry and Relationship to Corneal Topographical Parameters in Accelerated Corneal Crosslinking for the Treatment of Keratoconus.Journal of clinical medicine · 2026Article
- Impact of Corneal Crosslinking on Endothelial and Biomechanical Parameters in Keratoconus.Journal of clinical medicine · 2025Article
- Article
- Individual Risk Assessment and Prognostication of Outcomes After Corneal Cross-Linking.Journal of ophthalmology · 2025Article
- The impact of interrupted corneal collagen crosslinking (CXL) treatment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Review
- Article
- Intraocular pressure after combined photorefractive keratectomy and corneal collagen cross-linking for keratoconus.International ophthalmology · 2023Article
- The Underlying Relationship between Keratoconus and Down Syndrome.International journal of molecular sciences · 2022Review
- Keratoconus associated with hereditary sensory and autonomic neuropathy II.Indian journal of ophthalmology · 2022Article
- Sequence of events leading to diagnosis of keratoconus and its impact on quality of life.Indian journal of ophthalmology · 2021Article
- Changes of matrix metalloproteinases in the stroma after corneal cross-linking in rabbits.International journal of ophthalmology · 2021Article
- Simultaneous photorefractive keratectomy and accelerated collagen cross-linking in high-risk refractive surgery (Tehran protocol): 3-year outcomes.International ophthalmology · 2020Article
- Primary cilia in corneal development and disease.Zoological research · 2020Review
- Correlation between corneal demarcation line depth in epithelium-off and trans-epithelium accelerated corneal cross linking and keratoconus progression.International journal of ophthalmology · 2020Article
- Repeatability of curvature measurements in central and paracentral corneal areas of keratoconus patients using Orbscan and Pentacam.Journal of current ophthalmology · 2019Article
- Article
- Article
- Effectiveness and safety of accelerated (9 mW/cmEye (London, England) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo review the historical background and basic principles of collagen cross-linking, to bring together the data regarding the outcomes and complications of collagen cross-linking and finally to explore the efficacy and safety of new variations of this technique.
methodsA literature review was performed using PubMed and Scopus. The following keywords were used for literature search: cross linking, crosslinking, cross-linking, keratoconus, keratectasia.
resultsIn contrast to traditional treatment modalities for keratoconus (KCN), this new technique addresses the progression of the disease. Several clinical studies have been conducted to assess the efficacy of corneal collagen cross-linking (CXL) in the last decade. The results were promising as collagen cross-linking showed significant improvement in visual acuity and keratometric values. Moreover, initial results show that it is a safe procedure with few reported complications.
conclusionCXL is an emerging treatment method in ophthalmology that offers the possibility to effectively treat progressive KCN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.