Evidence map›Paper›PMID 29270410›Full record

ArticleFrontiers in veterinary science2017

Extracorporeal Shockwave Therapy Increases Growth Factor Release from Equine Platelet-Rich Plasma

Kathryn A Seabaugh, Merrilee Thoresen, Steeve Giguère

Open access · goldAbstract read
In one paragraph

Article in Frontiers in veterinary science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kathryn A SeabaughDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, United States.
Merrilee ThoresenDepartment of Large Animal Medicine, University of Georgia, Athens, GA, United States.
Steeve GiguèreDepartment of Large Animal Medicine, University of Georgia, Athens, GA, United States.
University of Georgia · USMississippi State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExtracorporeal shockwave therapy (ESWT) and platelet-rich plasma (PRP) are common treatments for soft tissue injuries in horses. Shockwave triggers cell specific responses to promote healing. Growth factors released from PRP also promote healing. It has been hypothesized that greater growth factor release would amplify the healing process. The combination of ESWT and PRP could promote healing in injured tendons and ligaments in the horse. The objective of this study was to determine if application of shockwaves to PRP samples increases the concentration of transforming growth factor-β MATERIALS AND

methodsPRP was produced from blood drawn from six horses. The PRP from each horse was exposed to the following treatments: (1) positive control (freeze-thaw cycle), (2) untreated negative control, or shockwaves with either (3) a "standard probe" (ESWT-S) with a 2 cm focal width and medium energy density or (4) a "power probe" (ESWT-P) with a 1 cm focal width and high energy density. After each treatment, the samples were centrifuged, and the supernatant was harvested. The supernatant was then used for growth factor quantification

resultsConcentrations of TGF-β DISCUSSION: These data indicate that the application of ESWT to PRP increases the expression of growth factors

conclusionThe combination of PRP and ESWT might result in synergism of two modalities previously utilized individually for tendon and ligament injuries in horses.

Indexed as

equineextracorporeal shockwave therapygrowth factorslamenessligamentplatelet-rich plasmaregenerative medicinetendon

Identifiers

PMID29270410
PMCPMC5726030
OpenAlexW2774864254

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.