ReviewFrontiers in pediatrics2017
Pediatric Thrombolysis: A Practical Approach.
Review in Frontiers in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Efficacy and safety of thrombolysis for pediatric venous thromboembolism: a systematic review and meta-analysis.Blood advances · 2025Pooled it
- Revised recommendations of the Italian Society of Pediatrics about the general management of Kawasaki disease.Italian journal of pediatrics · 2021Guideline
- Thrombolytic Use and Outcomes in Pediatric Congenital and Acquired Heart Disease: A Single-Center Quaternary Care Experience.Pediatric cardiology · 2026Article
- Venous Thromboembolism in Neonates, Children, and Adolescents: A Comprehensive Narrative Review of Risk Factors, Diagnosis, Treatment, and Prevention.Medicina (Kaunas, Lithuania) · 2026Review
- Advances in treatment and prevention of pulmonary thromboembolism associated with Mycoplasma pneumoniae pneumonia in children.Pediatric research · 2026Review
- Re-interventions Following Patent Ductus Arteriosus Stenting During the Inter-stage Period.Pediatric cardiology · 2026Review
- Pediatric venous thromboembolism: an illustrated review.Research and practice in thrombosis and haemostasis · 2026Review
- Procedural Framework for Combined Mechanical Thrombectomy and Continuous rtPA Thrombolysis in the Recanalization of Deep Cerebral Venous Thrombosis in a Pediatric Patient.Clinical neuroradiology · 2026Article
- Venous Intervention in Children: Current Practice and Controversies.Cardiovascular and interventional radiology · 2026Review
- Serum miR-34a as Indicator of Impaired Fibrinolytic Capacity in Pediatric Thrombosis Through Inadequate Regulation of the ACE/PAI-1 Axis.International journal of molecular sciences · 2025Article
- Pediatric Venous Thromboembolism: Considerations for the Interventional Radiologist.Seminars in interventional radiology · 2025Review
- Endovascular Management of Pediatric Deep Venous Thrombosis.Seminars in interventional radiology · 2025Review
- [Clinical characteristics and outcomes of 11 neonates with venous thrombosis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Endovascular reperfusion followed by delayed open aortic repair in stable acute type A aortic dissection with malperfusion syndrome: a single-center experience.Frontiers in medicine · 2025Article
- Systemic thrombolysis for a mechanical atrioventricular valve thrombosis in a child with a single-ventricle palliation at Fontan stage.JTCVS techniques · 2024Article
- Selective iliofemoral stent placement for complex pediatric cases: a decade of institutional experience.Pediatric radiology · 2024Article
- Treating a limb-threatening arterial clot in a newborn with catheter-directed thrombolysis.Journal of thrombosis and thrombolysis · 2023Article
- Catheter-directed thrombolysis for massive deep vein thrombosis in an adolescent with severe antithrombin deficiency.Clinical case reports · 2022Article
- Acute Management of High-Risk and Intermediate-Risk Pulmonary Embolism in Children: A Review.Chest · 2022Review
- Catheter-directed embolectomy for massive pulmonary embolism in a pediatric patient.SAGE open medical case reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of pediatric venous thromboembolic disease is increasing in hospitalized children. While the mainstay of treatment of pediatric thrombosis is anticoagulation, reports on the use of systemic thrombolysis, endovascular thrombolysis, and mechanical thrombectomy have steadily been increasing in this population. Thrombolysis is indicated in the setting of life- or limb-threatening thrombosis. Thrombolysis can rapidly improve venous patency thereby quickly ameliorating acute signs and symptoms of thrombosis and may improve long-term outcomes such as postthrombotic syndrome. Systemic and endovascular thrombolysis can result in an increase in minor bleeding in pediatric patients, compared with anticoagulation alone, and major bleeding events are a continued concern. Also, endovascular treatment is invasive and requires technical expertise by interventional radiology or vascular surgery, and such expertise may be lacking at many pediatric centers. The goal of this mini-review is to summarize the current state of knowledge of thrombolysis/thrombectomy techniques, benefits, and challenges in pediatric thrombosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.