Evidence map›Paper›PMID 29270348›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2017

3D Printing of Lotus Root-Like Biomimetic Materials for Cell Delivery and Tissue Regeneration.

Chun Feng, Wenjie Zhang, Cuijun Deng, Guanglong Li, Jiang Chang, Zhiyuan Zhang, Xinquan Jiang, Chengtie Wu

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Bioactive Inorganic Materials for Innervated Multi-Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chun FengState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. China.
Wenjie ZhangDepartment of Prosthodontics Oral Bioengineering and Regenerative Medicine Lab Shanghai Key Laboratory of Stomatology Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. China.
Cuijun DengState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. China.
Guanglong LiDepartment of Prosthodontics Oral Bioengineering and Regenerative Medicine Lab Shanghai Key Laboratory of Stomatology Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. China.
Jiang ChangState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. China.
Zhiyuan ZhangOral and Maxillofacial Surgery Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. China.
Xinquan JiangDepartment of Prosthodontics Oral Bioengineering and Regenerative Medicine Lab Shanghai Key Laboratory of Stomatology Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. China.
Chengtie WuState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. China.ORCID 0000-0002-5986-591X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomimetic materials have drawn more and more attention in recent years. Regeneration of large bone defects is still a major clinical challenge. In addition, vascularization plays an important role in the process of large bone regeneration and microchannel structure can induce endothelial cells to form rudimentary vasculature. In recent years, 3D printing scaffolds are major materials for large bone defect repair. However, these traditional 3D scaffolds have low porosity and nonchannel structure, which impede angiogenesis and osteogenesis. In this study, inspired by the microstructure of natural plant lotus root, biomimetic materials with lotus root-like structures are successfully prepared via a modified 3D printing strategy. Compared with traditional 3D materials, these biomimetic materials can significantly improve in vitro cell attachment and proliferation as well as promote in vivo osteogenesis, indicating potential application for cell delivery and bone regeneration.

Indexed as

biomimetic materialscell deliverylotus root‐like biomaterialstissue regeneration

Identifiers

PMID29270348
PMCPMC5737106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.