ReviewMaternal health, neonatology and perinatology2017
NEC-zero recommendations from scoping review of evidence to prevent and foster timely recognition of necrotizing enterocolitis.
Review in Maternal health, neonatology and perinatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Lipid enemas for meconium evacuation in preterm infants - a retrospective cohort study.BMC pediatrics · 2021Trial
- Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives.Gut microbes · 2025Review
- Differences between neonatal units with high and low rates of breast milk feeding for very preterm babies at discharge: a qualitative study of staff experiences.BMC pregnancy and childbirth · 2024Article
- Prevention Strategies and Management of Necrotizing Enterocolitis.Current treatment options in pediatrics · 2024Article
- Does extremely early expression of colostrum after very preterm birth improve mother's own milk quantity? A cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Necrotizing enterocolitis: current understanding of the prevention and management.Pediatric surgery international · 2024Review
- Low technology, mild controlled hypothermia for necrotizing enterocolitis treatment: an initiative to improve healthcare to preterm neonates.European journal of pediatrics · 2021Article
- Turkish Neonatal Society Necrotizing Enterocolitis Diagnosis, Treatment and Prevention Guidelines.Turkish archives of pediatrics · 2021Article
- Development of a framework of intervention strategies for point of care quality improvement at different levels of healthcare delivery system in India: initial lessons.BMJ open quality · 2021Article
- Optimizing Nutritional Strategies to Prevent Necrotizing Enterocolitis and Growth Failure after Bowel Resection.Nutrients · 2021Review
- Effects of standardized feeding protocol on growth velocity and necrotizing enterocolitis in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- A national survey of the enteral feeding practices in Canadian neonatal intensive care units.Paediatrics & child health · 2020Article
- New directions in necrotizing enterocolitis with early-stage investigators.Pediatric research · 2020Review
- Racial/ethnic disparities and human milk use in necrotizing enterocolitis.Pediatric research · 2020Article
- Grading the evidence to identify strategies to modify risk for necrotizing enterocolitis.Pediatric research · 2020Review
- Opportunities for the federal government to advance necrotizing enterocolitis research.Pediatric research · 2020Review
- Precision-based modeling approaches for necrotizing enterocolitis.Disease models & mechanisms · 2020Review
- Bowel Dilatation on Initial Plane Abdominal Radiography May Help to Assess the Severity of Necrotizing Enterocolitis in Preterm Infants.Children (Basel, Switzerland) · 2020Article
- Relationship of Necrotizing Enterocolitis Rates to Adoption of Prevention Practices in US Neonatal Intensive Care Units.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2019Article
- Prevention of necrotizing enterocolitis in premature infants - an updated review.World journal of clinical pediatrics · 2019Review
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
backgroundAlthough decades have focused on unraveling its etiology, necrotizing enterocolitis (NEC) remains a chief threat to the health of premature infants. Both modifiable and non-modifiable risk factors contribute to varying rates of disease across neonatal intensive care units (NICUs). PURPOSE: The purpose of this paper is to present a scoping review with two new meta-analyses, clinical recommendations, and implementation strategies to prevent and foster timely recognition of NEC.
methodsUsing the Translating Research into Practice (TRIP) framework, we conducted a stakeholder-engaged scoping review to classify strength of evidence and form implementation recommendations using GRADE criteria across subgroup areas: 1) promoting human milk, 2) feeding protocols and transfusion, 3) timely recognition strategies, and 4) medication stewardship. Sub-groups answered 5 key questions, reviewed 11 position statements and 71 research reports. Meta-analyses with random effects were conducted on effects of standardized feeding protocols and donor human milk derived fortifiers on NEC.
resultsQuality of evidence ranged from very low (timely recognition) to moderate (feeding protocols, prioritize human milk, limiting antibiotics and antacids). Prioritizing human milk, feeding protocols and avoiding antacids were strongly recommended. Weak recommendations (i.e. "probably do it") for limiting antibiotics and use of a standard timely recognition approach are presented. Meta-analysis of data from infants weighing <1250 g fed donor human milk based fortifier had reduced odds of NEC compared to those fed cow's milk based fortifier (OR = 0.36, 95% CI 0.13, 1.00; DISCUSSION: Evidence for NEC prevention is of sufficient quality to implement. Implementation that addresses system-level interventions that engage the whole team, including parents, will yield the best impact to prevent NEC and foster its timely recognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.