ArticleFrontiers in genetics2017
Adaptive Evolution of Energy Metabolism-Related Genes in Hypoxia-Tolerant Mammals.
Article in Frontiers in genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Advancing Marine Mammal Conservation Through Omics Tools and Integration of Indigenous Ecological Knowledge.Molecular ecology · 2026Review
- Gene Ontology-Based Comparative Transcriptomics Provides Evidence of Genetic Adaptations in theAnimals : an open access journal from MDPI · 2026Article
- Low hypoxia tolerance as a determinant of the proinflammatory phenotype: a trained immunity perspective.Frontiers in immunology · 2026Review
- Convergent evolution in high-altitude and marine mammals: Molecular adaptations to pulmonary fibrosis and hypoxia.Zoological research · 2024Article
- Article
- Complex II ambiguities-FADHThe Journal of biological chemistry · 2024Review
- Adaptive evolution of antioxidase-related genes in hypoxia-tolerant mammals.Frontiers in genetics · 2024Review
- New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae).BMC biology · 2023Article
- Characterizing the genetic basis of trait evolution in the Mexican cavefish.Evolution & development · 2022Article
- Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation.Zoological research · 2022Article
- The genome of an apodid holothuroid (Chiridota heheva) provides insights into its adaptation to a deep-sea reducing environment.Communications biology · 2022Article
- Integrative analysis identifies potential ferroptosis-related genes of hypoxia adaptation in yak.Frontiers in veterinary science · 2022Article
- Local adaptations of Mediterranean sheep and goats through an integrative approach.Scientific reports · 2021Article
- Hypoxia Tolerant Species: The Wisdom of Nature Translated into Targets for Stroke Therapy.International journal of molecular sciences · 2021Review
- Genomics of Adaptations in Ungulates.Animals : an open access journal from MDPI · 2021Review
- The evolutionary history of manatees told by their mitogenomes.Scientific reports · 2021Article
- An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins.Evolution, medicine, and public health · 2021Article
- Genomic divergence reveals unique populations among Indian Yaks.Scientific reports · 2020Article
- Natural Tolerance to Ischemia and Hypoxemia in Diving Mammals: A Review.Frontiers in physiology · 2019Review
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Animals that are able to sustain life under hypoxic conditions have long captured the imagination of biologists and medical practitioners alike. Although the associated morphological modifications have been extensively described, the mechanisms underlying the evolution of hypoxia tolerance are not well understood. To provide such insights, we investigated genes in four major energy metabolism pathways, and provide evidence of distinct evolutionary paths to mammalian hypoxia-tolerance. Positive selection of genes in the oxidative phosphorylation pathway mainly occurred in terrestrial hypoxia-tolerant species; possible adaptations to chronically hypoxic environments. The strongest candidate for positive selection along cetacean lineages was the citrate cycle signaling pathway, suggestive of enhanced aerobic metabolism during and after a dive. Six genes with cetacean-specific amino acid changes are rate-limiting enzymes involved in the gluconeogenesis pathway, which would be expected to enhance the lactate removal after diving. Intriguingly, 38 parallel amino acid substitutions in 29 genes were observed between hypoxia-tolerant mammals. Of these, 76.3% were radical amino acid changes, suggesting that convergent molecular evolution drives the adaptation to hypoxic stress and similar phenotypic changes. This study provides further insights into life under low oxygen conditions and the evolutionary trajectories of hypoxia-tolerant species.
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