Evidence map›Paper›PMID 29270169›Full record

ArticleFrontiers in immunology2017

Circulating Plasmablasts from Chronically Human Immunodeficiency Virus-Infected Individuals Predominantly Produce Polyreactive/Autoreactive Antibodies.

Hongyan Liao, Yangsheng Yu, Song Li, Yinshi Yue, Chuanmin Tao, Kaihong Su, Zhixin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Antibodies and Immunity During Kawasaki Disease.Frontiers in cardiovascular medicine · 2020
    Review
  4. B Cells and Antibodies in Kawasaki Disease.International journal of molecular sciences · 2019
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Hongyan LiaoDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Yangsheng YuDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States.
Song LiDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States.
Yinshi YueDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States.
Chuanmin TaoDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Kaihong SuDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States.
Zhixin ZhangDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States.
University of Nebraska Medical Center · USQilu Hospital of Shandong University · CNState Key Laboratory of BiotherapyWest China Hospital of Sichuan University · CN

Funding

Novel Neutrophil Autoantigens in Systemic Lupus ErythematosusR01AR059351 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SU, KAIHONG · 2011 to 2015
$1.5M
Accumulation of VH replacement products in HIV patientsR56AI098576 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, ZHIXIN · 2012 to 2012
$453k
Contribution of VH Replacement to B Cell Anti-HIV Immune ResponseR21AI073174 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, ZHIXIN · 2007 to 2008
$363k
NIAID NIH HHS R21 AI073174NIAID NIH HHS R56 AI098576NIAMS NIH HHS R01 AR059351
6 · The paper itself

Abstract

Understanding the B-cell response during chronic human immunodeficiency virus (HIV) infection is essential for eliciting broad and potent neutralizing antibodies (Abs). In this study, we analyzed the plasmablast repertoire of chronically HIV-infected individuals in combination with antiretroviral therapy (ART). Among the obtained 72 recombinant monoclonal antibodies (mAbs), 27.8% weakly bound to HIV gp140 and were non-neutralizing. Remarkably, 56.9% were polyreactive and 55.6% were autoreactive. The prominent feature of being polyreactive/autoreactive is not limited to anti-gp140 Abs. Furthermore, these polyreactive/autoreactive Abs displayed striking cross-reactivity with DWEYS in the

Indexed as

autoreactive antibodyB cellhuman immunodeficiency virusIg heavyplasmablastpolyreactive antibodyrepertoireVH replacement

Identifiers

PMID29270169
PMCPMC5723652
OpenAlexW2772019592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.