ReviewFrontiers in physiology2017
Stem Cells from Dental Pulp: What Epigenetics Can Do with Your Tooth.
Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MicroRNAs-mediated regulation of the differentiation of dental pulp-derived mesenchymal stem cells: a systematic review and bioinformatic analysis.Stem cell research & therapy · 2023Pooled it
- Epigenetic regulation of adipogenesis on dental stem cells: a focus on histone modifications.Molecular biology reports · 2026Review
- Inhibition of histone deacetylase 3 in dental mesenchyme regulates the development of tooth root.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Effect of TGF-β1 transfected dental pulp derived mesenchymal stem cells onIranian journal of basic medical sciences · 2025Article
- Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials.Bioactive materials · 2023Article
- A perspective: Regeneration of soft and hard tissues in the oral cavity, from research to clinical practice.Frontiers in dental medicine · 2023Article
- CD301b+ Macrophages as Potential Target to Improve Orthodontic Treatment under Mild Inflammation.Cells · 2022Article
- Genome-wide distribution of 5hmC in the dental pulp of mouse molars and incisors.Journal of biochemistry · 2022Article
- Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells.Stem cells international · 2022Review
- Progress in the Study of Non-Coding RNAs in Multidifferentiation Potential of Dental-Derived Mesenchymal Stem Cells.Frontiers in genetics · 2022Review
- The Role of Epigenetic in Dental and Oral Regenerative Medicine by Different Types of Dental Stem Cells: A Comprehensive Overview.Stem cells international · 2022Review
- miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition.International journal of oral science · 2021Article
- Similar Features, Different Behaviors: A Comparative In VitroStudy of the Adipogenic Potential of Stem Cells from Human Follicle, Dental Pulp, and Periodontal Ligament.Journal of personalized medicine · 2021Article
- JMJD3: a critical epigenetic regulator in stem cell fate.Cell communication and signaling : CCS · 2021Review
- Conversion of stem cells from apical papilla into endothelial cells by small molecules and growth factors.Stem cell research & therapy · 2021Article
- Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy?International journal of molecular sciences · 2021Review
- Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells.Bioengineered · 2020Article
- Regenerative Capacity of Dental Pulp Stem Cells: A Systematic Review.Journal of pharmacy & bioallied sciences · 2020Review
- The self-renewal dental pulp stem cell microtissues challenged by a toxic dental monomer.Bioscience reports · 2020Article
- Epigenetic Regulation of Adipogenic Differentiation by Histone Lysine Demethylation.International journal of molecular sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult stem cells have attracted scientific attention because they are able to self-renew and differentiate into several specialized cell types. In this context, human dental tissue-derived mesenchymal stem cells (hDT-MSCs) have emerged as a possible solution for repairing or regenerating damaged tissues. These cells can be isolated from primary teeth that are naturally replaced, third molars, or other dental tissues and exhibit self-renewal, a high proliferative rate and a great multilineage potential. However, the cellular and molecular mechanisms that determine lineage specification are still largely unknown. It is known that a change in cell fate requires the deletion of existing transcriptional programs, followed by the establishment of a new developmental program to give rise to a new cell lineage. Increasing evidence indicates that chromatin structure conformation can influence cell fate. In this way, reversible chemical modifications at the DNA or histone level, and combinations thereof can activate or inactivate cell-type-specific gene sequences, giving rise to an alternative cell fates. On the other hand, miRNAs are starting to emerge as a possible player in establishing particular somatic lineages. In this review, we discuss two new and promising research fields in medicine and biology, epigenetics and stem cells, by summarizing the properties of hDT-MSCs and highlighting the recent findings on epigenetic contributions to the regulation of cellular differentiation.
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Registered trials
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