Evidence map›Paper›PMID 29270002›Full record

ReviewDrug design, development and therapy2017

Gut microbiota-derived short-chain fatty acids and kidney diseases.

Lingzhi Li, Liang Ma, Ping Fu

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04428190 (Prebiotic Therapy to Improve Outcomes of Renal Transplant), which is not on this map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04428190 early_phase1unknown statusnot on this mapstarted 2022, after this paper: background citation

Prebiotic Therapy to Improve Outcomes of Renal Transplant

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2022 to 2024Enrolled60ConditionsKidney Transplant, ComplicationsArmsHuman Milk Oligosaccharides (HMO), Placebo
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 151 citations in OpenAlex.

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  11. Regulating the crosstalk betweenFrontiers in immunology · 2026
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Lingzhi LiKidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Liang MaKidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Ping FuKidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Sichuan University · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota and its metabolites play pivotal roles in host physiology and pathology. Short-chain fatty acids (SCFAs), as a group of metabolites, exert positive regulatory effects on energy metabolism, hormone secretion, immune inflammation, hypertension, and cancer. The functions of SCFAs are related to their activation of transmembrane G protein-coupled receptors and their inhibition of histone acetylation. Though controversial, growing evidence suggests that SCFAs, which regulate inflammation, oxidative stress, and fibrosis, have been involved in kidney disease through the activation of the gut-kidney axis; however, the molecular relationship among gut microbiota-derived metabolites, signaling pathways, and kidney disease remains to be elucidated. This review will provide an overview of the physiology and functions of SCFAs in kidney disease.

Indexed as

AcetylationFatty Acids, VolatileGastrointestinal MicrobiomeHistonesHumansInflammationKidney DiseasesReceptors, G-Protein-CoupledFatty Acids, VolatileHistonesReceptors, G-Protein-Coupledgut–kidney axisgut microbiomekidney diseasesshort-chain fatty acids

Identifiers

PMID29270002
PMCPMC5729884
OpenAlexW2772686323

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.