ArticleScientific reports2017
Amino acids as modulators of the European seabass, Dicentrarchus labrax, innate immune response: an in vitro approach.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Dietary Leucine Requirement and Its Effects on Growth, Immunity, Antioxidant Capacity and Protein Metabolism in Pacific White Shrimp, Penaeus vannamei.Marine biotechnology (New York, N.Y.) · 2026Article
- Article
- Review
- Tryptophan and Cortisol Modulate the Kynurenine and Serotonin Transcriptional Pathway in the Kidney ofAnimals : an open access journal from MDPI · 2023Article
- Oleic acid as potential immunostimulant in metabolism pathways of hybrid grouper fingerlings (Epinephelus fuscoguttatus × Epinephelus lanceolatus) infected with Vibrio vulnificus.Scientific reports · 2023Article
- An in-depth characterisation of European seabass intestinal segments for assessing the impact of an algae-based functional diet on intestinal health.Scientific reports · 2023Article
- L-methionine supplementation modulates IgMFrontiers in immunology · 2023Article
- Article
- Methionine and Tryptophan Play Different Modulatory Roles in the European Seabass (Frontiers in immunology · 2021Article
- Article
- Modulation of Crustacean Innate Immune Response by Amino Acids and Their Metabolites: Inferences From Other Species.Frontiers in immunology · 2020Review
- Stressors Due to Handling Impair Gut Immunity in Meagre (Frontiers in physiology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Teleost innate immune system is a most developed and powerful system in which fish highly rely throughout their lives. Conditions in aquaculture farms are particularly prone to disease, thus, health and welfare ensuring strategies are an urgent call to which nutrition is gradually becoming a most regarded achievement tool. This study intended to evaluate different amino acids' effect on immune-related mechanisms as well as their potential as enhancers of European seabass, Dicentrarchus labrax, leucocyte functioning. To achieve these goals, primary cultures of head-kidney leucocytes were established and kept in amino acid (glutamine, arginine, tryptophan or methionine) supplemented culture media in two doses. The effects of amino acids treatments were then evaluated after stimulation with either Vibrio anguillarum or Vibrio anguillarum lipopolysaccharides by measuring nitric oxide production, extracellular respiratory burst, ATP and arginase activities, and expression of immune-related genes. Glutamine, arginine and tryptophan showed to be particularly relevant regarding cell energy dynamics; arginine and tryptophan supplementation also resulted in down-regulation of important immune-related genes. Immune responses in cells treated with methionine were generally enhanced but further studies, particularly those of enzymes activity, are essential to complement gene expression results and to better understand this nutrient's immune role in fish.
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