ArticleNature communications2017
A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Abalone genomics reveals an ancient asymmetry axis and the multifunctionality of the mantle.Science advances · 2026Article
- Electrophysiological Profiling of Exocytosis during Early-Stage Development of the Zebrafish Lateral Line.eNeuro · 2026Article
- Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line.bioRxiv : the preprint server for biology · 2025Article
- Research Progress on MET, Tip Link, and Stereocilia Complex with Special Reference to Zebrafish.International journal of molecular sciences · 2025Review
- Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.eLife · 2025Article
- Protective Effect of Marine Peptide fromMarine drugs · 2024Article
- Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function.eLife · 2024Article
- Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function.bioRxiv : the preprint server for biology · 2024Article
- Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.bioRxiv : the preprint server for biology · 2024Article
- Sensory transduction in auditory hair cells-PIEZOs can't touch this.The Journal of general physiology · 2024Article
- The structure of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- An NIR-emitting cyanine dye with pyridinium groups: the impact of regio-bond connection on the photophysical properties.Chemical communications (Cambridge, England) · 2024Article
- Transmembrane Channel-Like (Tmc) Subunits Contribute to Frequency Sensitivity in the Zebrafish Utricle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- TMC function, dysfunction, and restoration in mouse vestibular organs.Frontiers in neurology · 2024Article
- Asymmetric mechanotransduction by hair cells of the zebrafish lateral line.Current biology : CB · 2023Article
- Physiological responses of mechanosensory systems in the head of larval zebrafish (Frontiers in robotics and AI · 2023Article
- Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish.Frontiers in molecular neuroscience · 2023Article
- Vestibular physiology and function in zebrafish.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Detection of water motion by the lateral line relies on mechanotransduction complexes at stereocilia tips. This sensory system is comprised of neuromasts, patches of hair cells with stereociliary bundles arranged with morphological mirror symmetry that are mechanically responsive to two opposing directions. Here, we find that transmembrane channel-like 2b (Tmc2b) is differentially required for mechanotransduction in the zebrafish lateral line. Despite similarities in neuromast hair cell morphology, three classes of these cells can be distinguished by their Tmc2b reliance. We map mechanosensitivity along the lateral line using imaging and electrophysiology to determine that a hair cell's Tmc2b dependence is governed by neuromast topological position and hair bundle orientation. Overall, water flow is detected by molecular machinery that can vary between hair cells of different neuromasts. Moreover, hair cells within the same neuromast can break morphologic symmetry of the sensory organ at the stereocilia tips.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.