ArticleScientific reports2017
New Types of Experiments Reveal that a Neuron Functions as Multiple Independent Threshold Units.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Fibrinogen and Neuroinflammation in the Neurovascular Unit in Stroke.Journal of inflammation research · 2025Review
- Critically synchronized brain waves form an effective, robust and flexible basis for human memory and learning.Scientific reports · 2023Article
- Brain inspired neuronal silencing mechanism to enable reliable sequence identification.Scientific reports · 2022Article
- A multilayer-multiplexer network processing scheme based on the dendritic integration in a single neuron.AIMS neuroscience · 2022Article
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- A Bidirectional Neural Interface SoC With Adaptive IIR Stimulation Artifact Cancelers.IEEE journal of solid-state circuits · 2021Article
- Considerations for Neuromorphic Supercomputing in Semiconducting and Superconducting Optoelectronic Hardware.Frontiers in neuroscience · 2021Article
- Fibrinogen and Neuroinflammation During Traumatic Brain Injury.Molecular neurobiology · 2020Review
- Brain experiments imply adaptation mechanisms which outperform common AI learning algorithms.Scientific reports · 2020Article
- Editorial: Network Communication in the Brain.Network neuroscience (Cambridge, Mass.) · 2020Article
- Spatially resolved dendritic integration: towards a functional classification of neurons.PeerJ · 2020Article
- Creative destruction: Sparse activity emerges on the mammal connectome under a simulated communication strategy with collisions and redundancy.Network neuroscience (Cambridge, Mass.) · 2020Article
- Partial decortication ameliorates dopamine depletion‑induced striatal neuron lesions in rats.International journal of molecular medicine · 2019Article
- Stationary log-normal distribution of weights stems from spontaneous ordering in adaptive node networks.Scientific reports · 2018Article
- Adaptive nodes enrich nonlinear cooperative learning beyond traditional adaptation by links.Scientific reports · 2018Article
- Less Might Be More: Conduction Failure as a Factor Possibly Limiting the Efficacy of Higher Frequencies in rTMS Protocols.Frontiers in neuroscience · 2018Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Neurons are the computational elements that compose the brain and their fundamental principles of activity are known for decades. According to the long-lasting computational scheme, each neuron sums the incoming electrical signals via its dendrites and when the membrane potential reaches a certain threshold the neuron typically generates a spike to its axon. Here we present three types of experiments, using neuronal cultures, indicating that each neuron functions as a collection of independent threshold units. The neuron is anisotropically activated following the origin of the arriving signals to the membrane, via its dendritic trees. The first type of experiments demonstrates that a single neuron's spike waveform typically varies as a function of the stimulation location. The second type reveals that spatial summation is absent for extracellular stimulations from different directions. The third type indicates that spatial summation and subtraction are not achieved when combining intra- and extra- cellular stimulations, as well as for nonlocal time interference, where the precise timings of the stimulations are irrelevant. Results call to re-examine neuronal functionalities beyond the traditional framework, and the advanced computational capabilities and dynamical properties of such complex systems.
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