Evidence map›Paper›PMID 29269844›Full record

ArticleMolecular psychiatry2019

Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function.

Max E Joffe, Chiaki I Santiago, Julie L Engers, Craig W Lindsley, P Jeffrey Conn

Abstract read
In one paragraph

Article in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Modulation of Hippocampal Network Oscillation by PICK1-Dependent Cell Surface Expression of mGlu3 Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  7. Review
  8. Advances in translating mGluPharmacology, biochemistry, and behavior · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Activating mGluBiological psychiatry · 2021
    Article
  17. Review
  18. Article
  19. Molecular Basis of Late-Life Depression.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Max E JoffeDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Chiaki I SantiagoVanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA.
Julie L EngersVanderbilt Center for Neuroscience Drug Discovery, Nashville, TN, 37232, USA.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
P Jeffrey ConnDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA. jeff.conn@vanderbilt.edu.
Vanderbilt University · US

Funding

REGULATION OF SIGNALING BY MGLUR5R01MH062646 · NIMH · VANDERBILT UNIVERSITY · PI P Jeffrey Conn, COLLEEN M NISWENDER · 2001 to 2026
$10.9M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUTTING, LAURIE E · 2015 to 2019
$7.1M
Functions of Metabotropic Glutamate Receptor SubtypesR37NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2014 to 2020
$3.5M
Postdoctoral Training in CNS Drug Discovery ResearchT32MH093366 · NIMH · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2011 to 2015
$1.0M
NICHD NIH HHS U54 HD083211NIMH NIH HHS R01 MH062646NIMH NIH HHS T32 MH093366NINDS NIH HHS R37 NS031373
6 · The paper itself

Abstract

Stress can precipitate or worsen symptoms of many psychiatric disorders by dysregulating glutamatergic function within the prefrontal cortex (PFC). Previous studies suggest that antagonists of group II metabotropic glutamate (mGlu) receptors (mGlu

Indexed as

Amino AcidsAmygdalaAnimalsExcitatory Amino Acid AntagonistsGlutamic AcidHumansMaleMiceMice, Inbred C57BLNeuronal PlasticityPrefrontal CortexPyramidal CellsReceptors, Metabotropic GlutamateStress, PhysiologicalAmino AcidsExcitatory Amino Acid AntagonistsGlutamic Acidmetabotropic glutamate receptor 3Receptors, Metabotropic Glutamate

Identifiers

PMID29269844
PMCPMC6013320
OpenAlexW2777325040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.