ArticleScientific reports2017
Using newborn screening analytes to identify cases of neonatal sepsis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Diagnostic utility of serum ferritin in culture proven bacterial infection: an observational study.BMC infectious diseases · 2026Observational
- Quantitative assessment of neonatal health using dried blood spot metabolite profiles and deep learning.Science translational medicine · 2026Article
- Review
- Transgenerational associations between newborn metabolic profiles and bronchopulmonary dysplasia in neonates born to mothers with an obese phenotype.Scientific reports · 2025Article
- Metabolomics in neonatal sepsis: A critical appraisal of current evidence.Computational and structural biotechnology journal · 2025Review
- The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels.Frontiers in nutrition · 2025Article
- Newborn screen metabolic panels reflect the impact of common disorders of pregnancy.Pediatric research · 2022Observational
- Prediction modelling in the early detection of neonatal sepsis.World journal of pediatrics : WJP · 2022Review
- Immunoreactive Trypsinogen and Free Carnitine Changes on Newborn Screening after Birth in Patients Who Develop Type 1 Diabetes.Nutrients · 2021Article
- Newborn metabolic vulnerability profile identifies preterm infants at risk for mortality and morbidity.Pediatric research · 2021Article
- Clinical Significance of the Serum lncRNA NORAD Expression in Patients with Neonatal Sepsis and Its Association with miR-410-3p.Journal of inflammation research · 2021Article
- Article
- Review
- Association between newborn screening analytes and hypoxic ischemic encephalopathy.Scientific reports · 2019Article
- Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors.Lipids in health and disease · 2019Article
- Using Self Organizing Maps to Compare Sepsis Patients from the Neonatal and Adult Intensive Care Unit.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019Article
- A novel way of determining gestational age upon the birth of a child.Journal of global healthReview
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Authors and funding
9 authors.
Funding
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Abstract
Neonatal sepsis is associated with high mortality and morbidity, yet challenges with available diagnostic approaches can lead to delays in therapy. Our study assessed whether newborn screening analytes could be utilized to identify associations with neonatal sepsis. We linked a newborn screening registry with health databases to identify cases of sepsis among infants born in Ontario from 2010-2015. Correlations between sepsis and screening analytes were examined within three gestational age groups (early preterm: <34 weeks; late preterm: 34-36 weeks; term: ≥37 weeks), using multivariable logistic regression models. We started with a model containing only clinical factors, then added groups of screening analytes. Among 793,128 infants, 4,794 were diagnosed with sepsis during the neonatal period. Clinical variables alone or in combination with hemoglobin values were not strongly predictive of neonatal sepsis among infants born at term or late preterm. However, model fit improved considerably after adding markers of thyroid and adrenal function, acyl-carnitines, and amino acids. Among infants born at early preterm gestation, neither clinical variables alone nor models incorporating screening analytes adequately predicted neonatal sepsis. The combination of clinical variables and newborn screening analytes may have utility in identifying term or late preterm infants at risk for neonatal sepsis.
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