Evidence map›Paper›PMID 29269831›Full record

ArticleScientific reports2017

Disposable aptamer-sensor aided by magnetic nanoparticle enrichment for detection of salivary cortisol variations in obstructive sleep apnea patients.

Renny Edwin Fernandez, Yogeswaran Umasankar, Pandiaraj Manickam, Jeffrey C Nickel, Laura R Iwasaki, Burt K Kawamoto, Kristen C Todoki, JoAnna M Scott, Shekhar Bhansali

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Renny Edwin FernandezBio-MEMS and Microsystems Laboratory, Department of Electrical and Computer Engineering, Florida International University, Miami, Florida, USA.
Yogeswaran UmasankarBiomolecular Sciences Institute, Florida International University, Miami, Florida, USA.ORCID 0000-0001-9713-8548
Pandiaraj ManickamBio-MEMS and Microsystems Laboratory, Department of Electrical and Computer Engineering, Florida International University, Miami, Florida, USA.
Jeffrey C NickelSchool of Dentistry, Departments of Orthodontics and Dentofacial Orthopedics and Oral and Craniofacial Sciences, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Laura R IwasakiSchool of Dentistry, Departments of Orthodontics and Dentofacial Orthopedics and Oral and Craniofacial Sciences, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Burt K KawamotoSchool of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Kristen C TodokiSchool of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, USA.
JoAnna M ScottSchool of Dentistry, Department of Oral and Craniofacial Sciences, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Shekhar BhansaliBio-MEMS and Microsystems Laboratory, Department of Electrical and Computer Engineering, Florida International University, Miami, Florida, USA. sbhansa@fiu.edu.
University of Missouri–Kansas City · USFlorida International University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a disposable point-of-care sensing platform specific to salivary cortisol detection. The sensor is inkjet printed on a paper substrate with a metalloporphyrin based macrocyclic catalyst ink that can electrochemically reduce cortisol, captured by aptamer functionalized magnetic nanoparticles. The sensor consists of a thin magnet disc, aligned at the back of the electrode, in order to populate the magnetic nanoparticle bound cortisol at the sensing electrode area. Proof of concept studies were performed to detect salivary cortisol levels in human subjects with high and low risks for obstructive sleep apnea (OSA). High selectivity was observed to salivary cortisol against a background of closely related steroids.

Indexed as

Magnetite NanoparticlesAdultDisposable EquipmentElectrodesFemaleHumansHydrocortisoneMaleMiddle AgedPoint-of-Care SystemsSalviaSleep Apnea, ObstructiveHydrocortisoneMagnetite Nanoparticles

Identifiers

PMID29269831
PMCPMC5740141
OpenAlexW2775544832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.