Evidence map›Paper›PMID 29269809›Full record

ArticleBone marrow transplantation2018

Access to alternative donor hematopoietic search and transplantation for acute leukemia in different macro-regions of Italy. A GITMO/IBMDR study.

Giuseppe Milone, Nicoletta Sacchi, Anna Gallina, Salvatore Leotta, Alessandra Picardi, Stefano Guidi, Giovanni Tripepi, Alessandro Rambaldi, Francesca Bonifazi

Abstract read
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In one paragraph

Article in Bone marrow transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Increasing access to allogeneic hematopoietic cell transplant: an international perspective.Hematology. American Society of Hematology. Education Program · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giuseppe MiloneHemopoietic Transplant Program, Division of Hematology, Azienda Ospedaliera Policlinico Vittorio Emanuele, Catania, Italy. giuseppe.milone@mail.com.ORCID http://orcid.org/0000-0002-7840-4414
Nicoletta SacchiItalian Bone Marrow Donor Registry, E.O. Ospedali Galliera, Genova, Italy.
Anna GallinaItalian Bone Marrow Donor Registry, E.O. Ospedali Galliera, Genova, Italy.
Salvatore LeottaHemopoietic Transplant Program, Division of Hematology, Azienda Ospedaliera Policlinico Vittorio Emanuele, Catania, Italy.
Alessandra PicardiHemopoietic Transplant Program, Department of Biomedicine e Prevention, University Tor Vergata, Rome, Italy.
Stefano GuidiHemopoietic Transplant Program, Division of Cell Therapy and Transfusion Medicine, Azienda Ospedaliera Careggi, Florence, Italy.
Giovanni TripepiInstitute of Physiology CNR, Ospedale Bianchi Melacrino Morelli, Reggio Calabria, Italy.
Alessandro RambaldiDepartment of Hematology and Oncology, University of Milan-, Ospedale Papa Giovanni XXIII, Bergamo, Italy.ORCID http://orcid.org/0000-0002-3739-7502
Francesca BonifaziHematology, University Hospital Sant'Orsola-, Malpighi, Bologna, Italy.ORCID http://orcid.org/0000-0003-1544-9911

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic Stem Cell Transplantation activity levels vary across European countries. No data are available on the homogeneity of access to the transplant procedure for patient with leukaemia, within any European country. We measured homogeneity of the rate of alternative donor search in patients affected by acute leukaemia resident in each Italian region and macro-region during years 2010-2013. A total of 2747 alternative donor searches were studied. Twenty-one percent of all donor searches were made through extra-regional migration. Rate of alternative donor searches varied among the country's regions and macro-regions. The rate of donor searches was 38% lower in South Italy than in North Italy, and the rate of alternative donor transplantations performed was 45% lower. A reduced rate of alternative donor search in South macro-region was observed in all age cohorts. Despite the overall allogeneic transplant rate in Italy is relatively high, there are wide regional differences in access to transplant from alternative donor. Extra-regional migration cannot completely compensate for the lower access to transplant of acute leukaemia patients living in those regions where transplant activity is low.

Indexed as

Acute DiseaseAdolescentAdultEuropeFemaleHematopoietic Stem Cell TransplantationHumansItalyLeukemiaMaleMiddle AgedRegistriesTissue Donors

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.