Evidence map›Paper›PMID 29269807›Full record

ArticleBone marrow transplantation2018

No association between donor telomere length and outcomes after allogeneic unrelated hematopoietic cell transplant in patients with acute leukemia.

Shahinaz M Gadalla, Tao Wang, David Loftus, Lyssa Friedman, Casey Dagnall, Michael Haagenson, Stephen R Spellman, Ljubomir Buturovic, Marsha Blauwkamp, Jason Shelton and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Bone marrow transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Article
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  7. Article
  8. Evaluation of a Machine Learning-Based Prognostic Model for Unrelated Hematopoietic Cell Transplantation Donor Selection.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2018
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Shahinaz M GadallaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. gadallas@mail.nih.gov.ORCID http://orcid.org/0000-0002-3255-8143
Tao WangCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA.
David LoftusTelomere Diagnostics, Menlo Park, CA, USA.
Lyssa Friedman
Casey DagnallCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7334-4718
Michael HaagensonCenter for International Blood and Marrow Transplant Research, Minneapolis, MN, USA.
Stephen R SpellmanCenter for International Blood and Marrow Transplant Research, Minneapolis, MN, USA.
Ljubomir ButurovicClinical Persona, Inc., East Palo Alto, CA, USA.
Marsha BlauwkampTelomere Diagnostics, Menlo Park, CA, USA.
Jason SheltonTelomere Diagnostics, Menlo Park, CA, USA.
Katharina FleischhauerInstitute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany.
Katharine C HsuMemorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2827-5324
Michael R VernerisPediatric BMT, University of Colorado, Aurora, CO, USA.
Damjan KrstajicClinical Persona, Inc., East Palo Alto, CA, USA.
Belynda HicksCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kristine JonesCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Stephanie J LeeCenter for International Blood and Marrow Transplant Research, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-2600-6390
Sharon A SavageDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6006-0740
Leidos (United States) · USNational Marrow Donor Program · USNational Cancer Institute · USEssen University Hospital · DEMedical College of Wisconsin · USMemorial Sloan Kettering Cancer Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Clinical Genetic Studies of Familial and Hereditary Cancer SyndromesZIACP010144 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$111.8M
Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Genetic Epidemiology of Telomere Maintenance and Cancer EtiologyZIACP010190 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$10.2M
Intramural NIH HHS ZIA CP010144NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA046934NCI NIH HHS U24 CA076518
6 · The paper itself

Abstract

Recent studies suggest improved survival in patients with severe aplastic anemia receiving hematopoietic cell transplant (HCT) from unrelated donors with longer telomeres. Here, we tested whether this effect is generalizable to patients with acute leukemia. From the Center for International Blood and Marrow Transplant Research (CIBMTR

Indexed as

Telomere HomeostasisUnrelated DonorsAcute DiseaseAdolescentAdultAgedChildChild, PreschoolFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansInfantInfant, NewbornLeukemiaLeukemia, Myeloid, Acute

Identifiers

PMID29269807
PMCPMC5898974
OpenAlexW2774818784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.