Evidence map›Paper›PMID 29269748›Full record

ArticleScientific reports2017

Attraction of Culex mosquitoes to aldehydes from human emanations.

Helena M Leal, Justin K Hwang, Kaiming Tan, Walter S Leal

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Mosquito Attractants.Journal of chemical ecology · 2021
    Review
  9. Article
  10. The olfactory basis of orchid pollination by mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
  12. Article
  13. Odor coding in the antenna of the tsetse flyProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  14. Article
  15. Reverse chemical ecology approach for the identification of an oviposition attractant forProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Helena M LealDepartment of Molecular and Cellular Biology, University of California-Davis, Davis, CA, 95616, USA.
Justin K HwangDepartment of Molecular and Cellular Biology, University of California-Davis, Davis, CA, 95616, USA.
Kaiming TanDepartment of Molecular and Cellular Biology, University of California-Davis, Davis, CA, 95616, USA.
Walter S LealDepartment of Molecular and Cellular Biology, University of California-Davis, Davis, CA, 95616, USA. wsleal@ucdavis.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anecdotes related to preferential mosquito bites are very common, but to date there is no complete explanation as to why one out of two people systematically receives more mosquito bites than the other when both are equally accessible. Here we tested the hypothesis that two constituents of skin emanations, 6-methyl-5-heptan-2-one (6-MHO) and geranylacetone (GA), are natural repellents and may account for differential attraction in different ratios. We studied skin emanations from two human subjects, confirmed in behavioral assays that female southern house mosquitoes are significantly more attracted to subject A (attractant) than to subject N (non-attractant), and tested their 6-MHO/GA ratios in a dual-choice olfactometer. Although repelling at high doses, 6-MHO/GA mixtures were not active at the levels emitted by human skin. We found, however, differential attraction elicited by the aldehydes in the ratios produced by subjects A and N. When tested in a dose commensurate with the level released from human skin and in the ratio produced by subject A, the aldehyde mixture significantly attracted mosquitoes. By contrast, an aldehyde mixture at the same ratio released by subject N did not attract mosquitoes. We, therefore, hypothesized that aldehydes may play a role in the commonly observed differential attraction.

Indexed as

AldehydesPheromonesAdolescentAnimalsCulexFemaleHumansInsect Bites and StingsInsect RepellentsKetonesMaleMiddle AgedSkinTerpenesAldehydesgeranylacetoneinsect attractantsInsect RepellentsKetonesPheromonesTerpenes

Identifiers

PMID29269748
PMCPMC5740115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.