ArticleNature communications2017
Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex.
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Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.
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143citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
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143 citing papers in PubMed, 255 citations in OpenAlex.
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- Tao-Hong-Si-Wu-Tang protects against methionine- and choline-deficient diet-induced hepatic steatosis in rats and is associated with inhibition of oxidative stress, inflammation, apoptosis, and pyroptosis.Frontiers in immunology · 2026Article
- Immune activation induced by dysregulated lipid metabolism in the pathogenesis of type 2 diabetes.World journal of diabetes · 2025Review
- The heterogeneity of monocyte-derived macrophages in MASH pathogenesis.Cell communication and signaling : CCS · 2025Review
- Recent advancements in tissue dissociation techniques for cell manufacturing single-cell analysis and downstream processing.Stem cells translational medicine · 2025Review
- Endoplasmic Reticulum Stress Drives VEGF Gene Expression in Monocytic Cells.Current issues in molecular biology · 2025Article
- Reactive Oxygen Species-Mediated TRPM2 Activation Facilitates Phagocytosis of Macrophages to Reverse Profibrotic Phenotype.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
83 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 4 institutions in 2 countries.
So Yeon KimLaboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon, 34141, Republic of Korea.ORCID http://orcid.org/0000-0003-1319-6164
Jong-Min JeongLaboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon, 34141, Republic of Korea.
Soo Jin KimGraduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Republic of Korea.
Wonhyo SeoLaboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon, 34141, Republic of Korea.
Myung-Ho KimGraduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Republic of Korea.
Won-Mook ChoiGraduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Republic of Korea.
Wonbeak YooGraduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Republic of Korea.
Jun-Hee LeeGraduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Republic of Korea.
Young-Ri ShimLaboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon, 34141, Republic of Korea.
Hyon-Seung YiDepartment of Internal Medicine, Chungnam National University School of Medicine, Daejeon, 35015, Republic of Korea.
Young-Sun LeeDepartment of Internal Medicine, Korea University College of Medicine, Seoul, 08308, Republic of Korea.ORCID http://orcid.org/0000-0001-6396-0859
Hyuk Soo EunDepartment of Internal Medicine, Chungnam National University School of Medicine, Daejeon, 35015, Republic of Korea.
Byung Seok LeeDepartment of Internal Medicine, Chungnam National University School of Medicine, Daejeon, 35015, Republic of Korea.
Kwangsik ChunDepartment of Surgery, Chungnam National University School of Medicine, Daejeon, 35015, Republic of Korea.
Suk-Jo KangDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Sun Chang KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Bin GaoNational Institutes of Health (NIH), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, MD, 20892, USA.
George KunosNational Institutes of Health (NIH), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, MD, 20892, USA.
Ho Min KimGraduate School of Medical Science and Engineering, KAIST, Daejeon, 34141, Republic of Korea.
Won-Il JeongLaboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon, 34141, Republic of Korea. wijeong@kaist.ac.kr.
Korea Advanced Institute of Science and Technology · KRChungnam National University · KRNational Institutes of Health · USKorea University · KR
Funding
Endocannabinoids And Energy HomeostasisZIAAA000350 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI KUNOS, GEORGE · 2009 to 2025
$28.4MAbstract
Reactive oxygen species (ROS) contribute to the development of non-alcoholic fatty liver disease. ROS generation by infiltrating macrophages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX) activation. Here, we show that palmitate-stimulated CD11b
Indexed as
EndocytosisAnimalsCD11b AntigenDiet, High-FatEnzyme ActivationHumansImmunophenotypingInflammationLiverLymphocyte Antigen 96MacrophagesMaleMiceMice, Inbred C57BLNADPH Oxidase 2Non-alcoholic Fatty Liver DiseaseCD11b AntigenCybb protein, mouseLy96 protein, mouseLymphocyte Antigen 96NADPH Oxidase 2Palmitic AcidReactive Oxygen SpeciesTlr4 protein, mouseToll-Like Receptor 4
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