SynthesisJournal of atherosclerosis and thrombosis2018
High Dietary Saturated Fat is Associated with a Low Risk of Intracerebral Hemorrhage and Ischemic Stroke in Japanese but not in Non-Japanese: A Review and Meta-Analysis of Prospective Cohort Studies.
Synthesis in Journal of atherosclerosis and thrombosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Effect of reducing saturated fat intake on cardiovascular disease in adults: an umbrella review.Frontiers in public health · 2024Pooled it
- Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies.BMC medicine · 2022Pooled it
- Pooled it
- Article
- Sex Differences in the Relationship Between Nutrient Intake and Mortality Results of the Shika Cohort Study.Nutrients · 2025Article
- Development and Validation of the Meiji Nutritional Profiling System per Serving Size.Nutrients · 2024Article
- Stroke Demographics, Risk Factors, Subtypes, Syndromes, Mechanisms and Inter-Ethnic Differences between Chinese, Malays and Indians in Singapore-A Hospital-Based Study.Journal of cardiovascular development and disease · 2024Article
- Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022.Journal of atherosclerosis and thrombosis · 2024Article
- Association of blood eicosapentaenoic acid levels with intracerebral hemorrhage during the COVID-19 pandemic: preliminary experience from a single-center in Japan.BMC neurology · 2022Article
- Article
- Association between Milk Intake and Incident Stroke among Japanese Community Dwellers: The Iwate-KENCO Study.Nutrients · 2021Article
- Nutritional Viewpoints on Eggs and Cholesterol.Foods (Basel, Switzerland) · 2021Review
- Association of Serum Fatty Acids at Admission with the Age of Onset of Intracerebral Hemorrhage.Nutrients · 2020Article
- Overview of Meta-Analyses: The Impact of Dietary Lifestyle on Stroke Risk.International journal of environmental research and public health · 2019Review
- Dietary Intake of Energy and Nutrients from Breakfast and Risk of Stroke in The Japanese Population: The Circulatory Risk in Communities Study (CIRCS).Journal of atherosclerosis and thrombosis · 2019Article
- Usual Dietary Intake and Risk of Stroke.Journal of atherosclerosis and thrombosis · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe associations between dietary saturated fatty acids and the risks of stroke subtypes in cohort studies were examined by a meta-analysis of separate ethnic Japanese and non-Japanese cohorts, and causes of their difference were elucidated.
methodLog hazard ratio (HR) with 95% confidence interval (CI) of the highest versus the lowest saturated fat intake from cohort studies were weighed by an inverse variance method to combine HRs.
resultsFive studies of intracerebral hemorrhage and 11 studies/comparisons of ischemic stroke were selected. A meta-analysis of intracerebral hemorrhage excluding subarachnoid hemorrhage showed a strong inverse association in Japanese (n=3, HR=0.55, 95% CI 0.32-0.94) but not in non-Japanese (n=2, HR=0.98, 95% CI 0.62-1.53). A meta-analysis of ischemic stroke showed a mild inverse association in Japanese (n=4, HR=0.82, 95% CI 0.71-0.93) but not in non-Japanese (n=7, HR= 0.93, 95% CI 0.84-1.03). The effect size of saturated fat in reducing the risk of stroke in Japanese was stronger for intracerebral hemorrhage (45% reduction) than for ischemic stroke (18% reduction).
conclusionsIn Japanese but not in non-Japanese, a diet high in saturated fat is associated with a low risk of intracerebral hemorrhage and ischemic stroke. This may be due to differences in the range of intake of saturated fat, genetic susceptibility, incidence of lacunar infarction, and/or confounding factors such as dietary proteins. An intervention study targeting Japanese will be required to verify the causality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.