Evidence map›Paper›PMID 29269680›Full record

ArticleInternal medicine (Tokyo, Japan)2018

Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A.

Hoshimi Kawaguchi, Hiroto Tsuboi, Mizuki Yagishita, Toshihiko Terasaki, Mayu Terasaki, Masaru Shimizu, Fumika Honda, Ayako Ohyama, Hiroyuki Takahashi, Haruka Miki and 6 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Pericarditis in Systemic Rheumatologic Diseases.Current cardiology reports · 2020
    Review
  6. The Two-Faced Cytokine IL-6 in Host Defense and Diseases.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Hoshimi KawaguchiDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Hiroto TsuboiDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Mizuki YagishitaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Toshihiko TerasakiDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Mayu TerasakiDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Masaru ShimizuDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Fumika HondaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Ayako OhyamaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Hiroyuki TakahashiDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Haruka MikiDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Masahiro YokosawaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Hiromitsu AsashimaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Shinya HagiwaraDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Yuya KondoDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Isao MatsumotoDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
Takayuki SumidaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
University of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult-onset Still disease (AOSD) is a systemic inflammatory disease characterized by fever, arthritis and rash. Corticosteroids represent a promising therapeutic option for AOSD; however, some resistant cases require immunosuppressants and biologic agents. We herein report the case of a 29-year-old Japanese man with severe AOSD, accompanied by constrictive pericarditis (CP) and pleuritis. Although 2 courses of steroid pulse and subsequent high-dose of prednisolone and cyclosporine A improved the patient's CP and pleuritis, his fever and inflammatory responses persisted. Tocilizumab (TCZ) was added to his treatment, which resulted in a rapid remission. This case suggests the usefulness of TCZ in the treatment of severe AOSD with CP and pleuritis.

Indexed as

Adrenal Cortex HormonesAdultAntibodies, Monoclonal, HumanizedAntirheumatic AgentsAsian PeopleCyclosporineHumansMalePericarditis, ConstrictivePleurisyStill's Disease, Adult-OnsetTreatment OutcomeAdrenal Cortex HormonesAntibodies, Monoclonal, HumanizedAntirheumatic AgentsCyclosporinetocilizumabadult-onset Still diseaseconstrictive pericarditispleuritistocilizumab

Identifiers

PMID29269680
PMCPMC5919867
OpenAlexW2779135178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.