Evidence map›Paper›PMID 29269645›Full record

ArticleInternal medicine (Tokyo, Japan)2018

A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges.

Erika Matsumura-Matsuda, Motohiro Sekiya, Miyoko Omoto-Inuzuka, Kana Santo, Akito Shikama, Motoko Kuba, Yoko Sugano, Hitoshi Iwasaki, Shigeru Yatoh, Taiki Sato and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. TheInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Erika Matsumura-MatsudaDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Motohiro SekiyaDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Miyoko Omoto-InuzukaDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Kana SantoDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Akito ShikamaDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Motoko KubaDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Yoko SuganoDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Hitoshi IwasakiDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Shigeru YatohDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Taiki SatoDepartment of Pathology, University of Tsukuba, Japan.
Hisato HaraDepartment of Surgery, University of Tsukuba, Japan.
Kazuhiro TakekoshiDepartment of Molecular Laboratory Medicine, University of Tsukuba, Japan.
Hiroaki SuzukiDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
Hitoshi ShimanoDepartment of Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Japan.
University of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a case of pheochromocytoma occurring in the course of Parkinson's disease. The coexistence of these two disease is extremely rare, with only four cases hitherto reported across the public databases. It is also noteworthy that biochemical tests, which are critical for the diagnosis of pheochromocytoma, are severely confounded by dopaminergic medications for Parkinson's disease, highlighting the importance of image-based modalities in this setting. We further attempted to gain insight into the potential molecular mechanisms, proposing that hypoxia-inducible factor signaling could make these two diseases mutually exclusive, while excessive reactive oxygen species could enable their coexistence.

Indexed as

Adrenal Gland NeoplasmsAgedAsian PeopleDopamine AgentsHumansMaleParkinson DiseasePheochromocytomaRare DiseasesSignal TransductionDopamine Agentsdopaminergic medicationsHIF-ROSParkinson's diseasepheochromocytomarare coexistence

Identifiers

PMID29269645
PMCPMC5919857
OpenAlexW2775995186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.