Evidence map›Paper›PMID 29269561›Full record

ArticleThe Journal of experimental medicine2018

Shared cancer neoantigens: Making private matters public.

Christopher A Klebanoff, Jedd D Wolchok

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Isolation of mitochondrial mutation-specific T cell receptors.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  5. Article
  6. Shared neoantigens for cancer immunotherapy.Molecular therapy. Oncology · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Neoantigen immunotherapy: a novel treatment for bladder cancer.Exploration of targeted anti-tumor therapy · 2025
    Review
  11. Article
  12. Public neoantigens in breast cancer immunotherapy (Review).International journal of molecular medicine · 2024
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Neoantigens: promising targets for cancer therapy.Signal transduction and targeted therapy · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher A KlebanoffMemorial Sloan Kettering Cancer Center (MSKCC); Parker Institute for Cancer Immunotherapy; MSKCC Center for Cell Engineering; Weill Cornell Medical and Graduate Schools, New York, NY.ORCID 0000-0001-9645-3896
Jedd D WolchokMemorial Sloan Kettering Cancer Center (MSKCC); Parker Institute for Cancer Immunotherapy; MSKCC Center for Cell Engineering; Weill Cornell Medical and Graduate Schools, New York, NY.
Memorial Sloan Kettering Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of JEM, Chheda et al. (https://doi.org/10.1084/jem.20171046) report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, thereby creating a "public" neoantigen.

Indexed as

HistonesMutationCell- and Tissue-Based TherapyEpitopes, T-LymphocyteGliomaHumansEpitopes, T-LymphocyteHistones

Identifiers

PMID29269561
PMCPMC5748868
OpenAlexW2779593858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.