Evidence map›Paper›PMID 29269497›Full record

ArticleApplied and environmental microbiology2018

Covalent Structure and Bioactivity of the Type AII Lantibiotic Salivaricin A2.

Mengxin Geng, Frank Austin, Ronald Shin, Leif Smith

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Journal of microbiology and biotechnology · 2025
    Article
  7. Microbial threads in the tapestry of rheumatoid arthritis.The Journal of clinical investigation · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Antimicrobial Peptides: An Update on Classifications and Databases.International journal of molecular sciences · 2021
    Review
  14. Bacteriocin Production by Beta-Hemolytic Streptococci.Pathogens (Basel, Switzerland) · 2021
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Mengxin GengDepartment of Biology, College of Science, Texas A&M University, College Station, Texas, USA.
Frank AustinDepartment of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA.
Ronald ShinCentral Alabama High-Field NMR Facility, Structural Biology Shared Facility, Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Leif SmithDepartment of Biology, College of Science, Texas A&M University, College Station, Texas, USA jsmith@bio.tamu.edu.
Texas A&M University · USMississippi State University · USUniversity of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
800 MHz NMR Spectrometer for the Central Alabama High-Field NMR FacilityS10RR022994 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KRISHNA, NEPALLI RAMA · 2009 to 2009
$2.0M
NCI NIH HHS P30 CA013148NCRR NIH HHS S10 RR022994
6 · The paper itself

Abstract

Lantibiotics are a class of lanthionine-containing, ribosomally synthesized, and posttranslationally modified peptides (RiPPs) produced by Gram-positive bacteria. Salivaricin A2 belongs to the type AII lantibiotics, which are generally considered to kill Gram-positive bacteria by binding to the cell wall precursor lipid II via a conserved ring A structure. Salivaricin A2 was first reported to be isolated from a probiotic strain,

Indexed as

BacteriaBacterial ProteinsBacteriocinsStreptococcus salivariusBacterial ProteinsBacteriocinssalivaricin Abioactivitycovalent structurelanthipeptidelantibioticsalivaricin A2

Identifiers

PMID29269497
PMCPMC5812933
OpenAlexW2778215396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.