Evidence map›Paper›PMID 29269494›Full record

ArticleApplied and environmental microbiology2018

Promising Prebiotic Candidate Established by Evaluation of Lactitol, Lactulose, Raffinose, and Oligofructose for Maintenance of a Lactobacillus-Dominated Vaginal Microbiota.

Stephanie L Collins, Amy McMillan, Shannon Seney, Charlotte van der Veer, Remco Kort, Mark W Sumarah, Gregor Reid

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05882851 (Investigation of the Effect of Nutrition and Risk Factors on the Failure of Vaginitis Treatment), which is not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05882851 completednot on this mapstarted 2022, after this paper: background citation

Investigation of the Effect of Nutrition and Risk Factors on the Failure of Vaginitis Treatment

TypeobservationalSponsorOsmaniye Korkut Ata UniversityRan2022 to 2022Enrolled106ConditionsVaginitisArmsdetermination of the current nutritional status of patients
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Contribution ofFrontiers in cellular and infection microbiology · 2021
    Pooled it
  2. Trial
  3. Vaginal formulations selectively target Lactobacillus iners and Candida spp. while preserving Lactobacillus crispatus.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  4. Article
  5. Review
  6. The Gut-Vagina Axis.Microorganisms · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. PeerJ · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Stephanie L CollinsDepartment of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-2773-646X
Amy McMillanDepartment of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada.
Shannon SeneyCanadian Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada.
Charlotte van der VeerPublic Health Laboratory, Public Health Service of Amsterdam (GGD), Amsterdam, The Netherlands.
Remco KortMolecular Cell Physiology, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands.
Mark W SumarahAgriculture and Agri-Food Canada, London, Ontario, Canada.
Gregor ReidDepartment of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada gregor@uwo.ca.ORCID https://orcid.org/0000-0001-9658-5696
Western University · CAAgriculture and Agri-Food Canada · CAGGD Amsterdam · NLLawson Health Research Institute · CANetherlands Organisation for Applied Scientific Research · NL

Funding

CIHR
6 · The paper itself

Abstract

Perturbations to the vaginal microbiota can lead to dysbiosis, including bacterial vaginosis (BV), which affects a large portion of the female population. In a healthy state, the vaginal microbiota is characterized by low diversity and colonization by

Indexed as

DysbiosisFemaleHumansLactobacillusMass SpectrometryMetabolomicsMicrobiotaOligosaccharidesPrebioticsRNA, BacterialRNA, Ribosomal, 16SSequence Analysis, RNASugar AlcoholsVaginalactitolOligosaccharidesPrebioticsRNA, BacterialRNA, Ribosomal, 16SSugar Alcoholsbacterial vaginosislactitollactobacillilactuloseoligofructoseprebioticsraffinosevaginal microbiota

Identifiers

PMID29269494
PMCPMC5812932
OpenAlexW2779053224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.