Evidence map›Paper›PMID 29269445›Full record

ArticleScience (New York, N.Y.)2017

Recurrent infection progressively disables host protection against intestinal inflammation.

Won Ho Yang, Douglas M Heithoff, Peter V Aziz, Markus Sperandio, Victor Nizet, Michael J Mahan, Jamey D Marth

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  14. Cardio-Rheumatic Diseases: Inflammasomes Behaving Badly.International journal of molecular sciences · 2025
    Review
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  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Won Ho YangCenter for Nanomedicine, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0002-6090-7101
Douglas M HeithoffCenter for Nanomedicine, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0001-8954-2516
Peter V AzizCenter for Nanomedicine, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0001-8957-100X
Markus SperandioWalter-Brendel-Centre for Experimental Medicine, Ludwig-Maximilians-University, Munich, Germany.ORCID 0000-0002-7689-3613
Victor NizetDepartment of Pediatrics and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-3847-0422
Michael J MahanCenter for Nanomedicine, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Jamey D MarthCenter for Nanomedicine, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. jmarth@sbpdiscovery.com.ORCID 0000-0001-9323-1649
University of California, Santa Barbara · USLudwig-Maximilians-Universität München · DEUniversity of Montana · US

Funding

Protein Glycosylation in the Coagulopathy and Inflammation of SepsisP01HL131474 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ESKO, JEFFREY D · 2016 to 2025
$26.2M
Glycoprotein Remodeling in the Vasculopathy and Coagulopathy of SepsisR01HL125352 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MARTH, JAMEY, NIZET, VICTOR · 2014 to 2018
$3.6M
NHLBI NIH HHS P01 HL131474NHLBI NIH HHS R01 HL125352
6 · The paper itself

Abstract

Intestinal inflammation is the central pathological feature of colitis and the inflammatory bowel diseases. These syndromes arise from unidentified environmental factors. We found that recurrent nonlethal gastric infections of Gram-negative

Indexed as

Salmonella typhimuriumAlkaline PhosphataseAnimalsbeta-Galactoside alpha-2,3-SialyltransferaseColonEnzyme InhibitorsInflammatory Bowel DiseasesLipopolysaccharidesMiceMice, Inbred C57BLNeuraminidaseRecurrenceSalmonella Food PoisoningSialyltransferasesToll-Like Receptor 4ZanamivirAlkaline Phosphatasebeta-Galactoside alpha-2,3-SialyltransferaseEnzyme InhibitorsLipopolysaccharidesNeuraminidaseSialyltransferasesTlr4 protein, mouseToll-Like Receptor 4Zanamivir

Identifiers

PMID29269445
PMCPMC5824721
OpenAlexW2777913435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.