ArticleCMAJ open2017
Case-control study of household contacts to examine immunological protection from
Open access · diamondAbstract read
In one paragraph
Article in CMAJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Atypical pertussis: Family cluster case series and primary care management strategies.Journal of family medicine and primary care · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 8 institutions in 2 countries.
Shelly BolotinAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Caitlin JohnsonAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Susan QuachAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Ardith AmbroseAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Sarah DeCoutereAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Shelley L DeeksAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Steven DrewsAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Amna FaheemAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Karen GreenAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Scott A HalperinAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Linda HoangAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Frances JamiesonAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Tobias KollmannAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Alex Marchand-AustinAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Deirdre McCormackAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Allison McGeerAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Michelle MurtiAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Alison Orth BbaAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Anu RebbapragadaAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Otto G VanderkooiAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Jun WangAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Bryna WarshawskyAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Natasha S CrowcroftAffiliations: Public Health Ontario (Bolotin, Johnson, Quach, Deeks, Jamieson, Marchand-Austin, Warshawsky, Crowcroft); University of Toronto (Bolotin, Deeks, Jamieson, Crowcroft), Toronto, Ont.; Canadian Center for Vaccinology (Ambrose, DeCoutere, Halperin, Wang), Halifax, NS; Department of Laboratory Medicine and Pathology (Drews), University of Alberta; ProvLab Alberta (Drews), Edmonton, Alta.; North York General Hospital (Faheem); Mount Sinai Hospital (Green, McGeer), Toronto, Ont.; Department of Microbiology and Immunology (Halperin), Dalhousie University, Halifax, NS; British Columbia Centre for Disease Control (Hoang); Child and Family Research Institute (Kollmann), Vancouver, BC; McGill University Health Centre (McCormack), Montréal, Que.; Fraser Health Authority (Murti, Orth), Surrey, BC; Gamma Dynacare (Rebbapragada), Brampton, Ont.; University of Calgary (Vanderkooi), Calgary, Alta.
Canadian Immunization Research Network Provincial Collaborative Network
Fraser Health · CAPublic Health Ontario · CABC Centre for Disease Control · CAFamily Research Institute · USUniversity of Alberta · CAChild and Family Research Institute · CADalhousie University · CAYork General Hospital · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is mounting evidence that the recent resurgence of pertussis in many countries is in part related to the acellular vaccine, which has been administered in Canada since 1997. This vaccine elicits a different cell-mediated immune response than the previously used whole-cell vaccine, and its effectiveness wanes over time. The aim of this study is to understand the immunological, demographic and clinical factors that mediate protection from pertussis on exposure.
methodsThis is a household case-control study protocol. Following notification of an index case in a household, a study team will conduct a home visit to collect data and biological specimens. The study team will return to the household 8 weeks from the onset of illness in the index case. The Th1, Th2 and Th17 responses, cytokine expression, IgG subclass, blood cell counts and presence of
interpretationThe results of this study will be essential for understanding the immune response required for protection from infection with
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