Evidence map›Paper›PMID 29269422›Full record

ArticleScience (New York, N.Y.)2018

Dicer uses distinct modules for recognizing dsRNA termini.

Niladri K Sinha, Janet Iwasa, Peter S Shen, Brenda L Bass

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 122 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Journal of virology · 2025
    Article
  7. Biochemical and structural basis of Dicer helicase function unveiled by resurrecting ancient proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. The PAZ domain ofRNA (New York, N.Y.) · 2025
    Article
  10. The biogenesis and regulation of animal microRNAs.Nature reviews. Molecular cell biology · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Dicer-2 mutations inThe Journal of general virology · 2024
    Article
  18. Article
  19. eLife · 2024
    Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brenda L BassDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA. bbass@biochem.utah.edu peter.shen@biochem.utah.edu.ORCID 0000-0003-1728-2254
University of Utah · US

Funding

Mechanistic insights into Dicer, a double-stranded RNA processing enzymeR01GM121706 · NIGMS · UNIVERSITY OF UTAH · PI BASS, BRENDA L. · 2017 to 2020
$1.5M
NIGMS NIH HHS R01 GM121706
6 · The paper itself

Abstract

Invertebrates rely on Dicer to cleave viral double-stranded RNA (dsRNA), and

Indexed as

Adenosine TriphosphateAnimalsCryoelectron MicroscopyDrosophila ProteinsProtein BindingProtein Structure, TertiaryRibonuclease IIIRNA CleavageRNA, Double-StrandedRNA HelicasesRNA, Small InterferingRNA, ViralSubstrate SpecificityAdenosine TriphosphateDCR-2 protein, DrosophilaDrosophila ProteinsRibonuclease IIIRNA, Double-StrandedRNA HelicasesRNA, Small InterferingRNA, Viral

Identifiers

PMID29269422
PMCPMC6154394
OpenAlexW2777841695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.